SillaJen, Inc.
SillaJen, Inc., founded in 2006 and listed on KOSDAQ in 2016, develops the oncolytic virus immunotherapy Pexa-Vec.
As of 2026-10-10, SillaJen, Inc. has 1 Korean MFDS drug approval, 23 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
Price
Change
Market cap
Business overview
Source: DART corporate disclosureSillaJen, Inc. was founded in March 2006 to develop anticancer drugs and listed on the KOSDAQ market in December 2016. The company is developing the oncolytic virus immunotherapy Pexa-Vec and mitotic checkpoint inhibitors targeting TTK and PLK1, while its pharmaceutical division has obtained approval for and markets five injectable prescription products. Pexa-Vec's Phase 3 hepatocellular carcinoma trial (PHOCUS) was terminated early on August 2, 2019, and SillaJen also operates an anticancer drug development and commerce business alongside its prescription drug R&D and sales division.
Products & technology
- Pexa-VecOncolytic virus immunotherapy under development for multiple solid tumors
- 프로파인퓨전주Injectable prescription drug
- 뉴아미노펜프리믹스주Injectable prescription drug
- 이브포프리믹스주Injectable prescription drug
- 페라미비르주Injectable prescription drug
- 펜타블루5주Injectable prescription drug
Regulatory approvals
data.go.kr1 Korean MFDS drug approvals · 2021
- MFDS drugNewpropa Injection2021-03-15Drug · Prescription · Approval202102323
Clinical trials
data.go.kr3 MFDS clinical trial authorisations · 2015–2023 (Phase 1 2 · Phase 3 1)
- Phase 1BAL08912023-04-12
12 trial sites
- Phase 3Pexa-Vec(Pexastimogene Devacirepvec)2016-04-29
20 trial sites
- Phase 1SJ-103β2015-09-11
1 trial site
Global clinical trials
ClinicalTrials.gov · sponsor-matchedPhase 1 · Recruiting · 2022-12 · NCT05768932
Phase 1/2 · Completed · 2018-06 · NCT03294083
Phase 3 · Completed · 2015-10 · NCT02562755
R&D and key agreements
Source: DART corporate disclosure펙사벡(Pexa-Vec) · 간암 등 고형암 · 임상 3상(PHOCUS, 간암, 조기종료) · The Phase 3 trial (PHOCUS) for hepatocellular carcinoma was terminated early on August 2, 2019.
유사분열 체크포인트 억제제(MCI) · 연구개발 진행중 · Under development to inhibit TTK and PLK1 kinases and disrupt the cancer cell cycle.
Key disclosures
KRX KIND via OpenDARTShow 11 more events
Publications
PubMed · affiliation-matched- Identification of a novel isoform of Slc26a4 by single-cell RNA-sequencing of pendrin-expressing cells in the cochlea.
Human genetics · 2026-07 · Koh JY, Affortit C, Homma K 외 16
- Oncolytic vaccinia virus JX-594 shows subtype-specific activity and candidate biomarkers in gastric cancer cell lines.
Scientific reports · 2026-05 · Kim JH, Kim Y, Shin Y 외 8
- CD55-displaying oncolytic vaccinia virus treated metastatic cancers by evading the effect of host innate and adaptive humoral responses.
Molecular therapy : the journal of the American Society of Gene Therapy · 2026-05 · Kim E, Yang Y, Won S 외 8
- BAP1 as a predictive biomarker of therapeutic response to oncolytic vaccinia virus for metastatic renal cell carcinoma therapy.
Cancer immunology, immunotherapy : CII · 2025-08 · Park JS, Jang WS, Lee ME 외 4
- PHOCUS: A Phase 3, Randomized, Open-Label Study of Sequential Treatment with Pexa-Vec (JX-594) and Sorafenib in Patients with Advanced Hepatocellular Carcinoma.
Liver cancer · 2024-06 · Abou-Alfa GK, Galle PR, Chao Y 외 11
- PD-1 inhibitor plus oncolytic vaccinia virus is a safe and effective treatment option for metastatic renal cell carcinoma.
Cancer cell international · 2024-01 · Park JS, Lee ME, Kim J 외 5
- Generation of novel oncolytic vaccinia virus with improved intravenous efficacy through protection against complement-mediated lysis and evasion of neutralization by vaccinia virus-specific antibodies.
Journal for immunotherapy of cancer · 2023-01 · Lee N, Jeon YH, Yoo J 외 7
- Oncolytic Vaccinia Virus Augments T Cell Factor 1-Positive Stem-like CD8+ T Cells, Which Underlies the Efficacy of Anti-PD-1 Combination Immunotherapy.
Biomedicines · 2022-03 · Jeon YH, Lee N, Yoo J 외 8
- Systemic Injection of Oncolytic Vaccinia Virus Suppresses Primary Tumor Growth and Lung Metastasis in Metastatic Renal Cell Carcinoma by Remodeling Tumor Microenvironment.
Biomedicines · 2022-01 · Park JS, Lee ME, Jang WS 외 5
- Cancer Stem Cells in the Immune Microenvironment.
Advances in experimental medicine and biology · 2021-01 · Lee DS, Oh K
Show 13 more publications
- Oncolytic vaccinia virus reinvigorates peritoneal immunity and cooperates with immune checkpoint inhibitor to suppress peritoneal carcinomatosis in colon cancer.
Journal for immunotherapy of cancer · 2020-11 · Lee YS, Lee WS, Kim CW 외 9
- Tumor Microenvironment Remodeling by Intratumoral Oncolytic Vaccinia Virus Enhances the Efficacy of Immune-Checkpoint Blockade.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2019-03 · Chon HJ, Lee WS, Yang H 외 9
- Vaccinia-based oncolytic immunotherapy Pexastimogene Devacirepvec in patients with advanced hepatocellular carcinoma after sorafenib failure: a randomized multicenter Phase IIb trial (TRAVERSE).
Oncoimmunology · 2019-01 · Moehler M, Heo J, Lee HC 외 34
- Gene expression profiling of hematologic malignant cell lines resistant to oncolytic virus treatment.
Oncotarget · 2017-01 · Lee NH, Kim M, Oh SY 외 3
- Relationship between insulin-like growth factor axis gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX.
Oncotarget · 2016-05 · Oh SY, Shin A, Kim SG 외 4
- Phase 1b Trial of Biweekly Intravenous Pexa-Vec (JX-594), an Oncolytic and Immunotherapeutic Vaccinia Virus in Colorectal Cancer.
Molecular therapy : the journal of the American Society of Gene Therapy · 2015-09 · Park SH, Breitbach CJ, Lee J 외 13
- Pexa-Vec double agent engineered vaccinia: oncolytic and active immunotherapeutic.
Current opinion in virology · 2015-08 · Breitbach CJ, Parato K, Burke J 외 3
- Complement inhibition prevents oncolytic vaccinia virus neutralization in immune humans and cynomolgus macaques.
Molecular therapy : the journal of the American Society of Gene Therapy · 2015-06 · Evgin L, Acuna SA, Tanese de Souza C 외 19
- Phase 1 study of intratumoral Pexa-Vec (JX-594), an oncolytic and immunotherapeutic vaccinia virus, in pediatric cancer patients.
Molecular therapy : the journal of the American Society of Gene Therapy · 2015-03 · Cripe TP, Ngo MC, Geller JI 외 12
- The emerging therapeutic potential of the oncolytic immunotherapeutic Pexa-Vec (JX-594).
Oncolytic virotherapy · 2015-01 · Breitbach CJ, Bell JC, Hwang TH 외 2
- A Phase 2, Open-Label, Randomized Study of Pexa-Vec (JX-594) Administered by Intratumoral Injection in Patients with Unresectable Primary Hepatocellular Carcinoma.
Methods in molecular biology (Clifton, N.J.) · 2015-01 · Breitbach CJ, Moon A, Burke J 외 2
- First-in-man study of western reserve strain oncolytic vaccinia virus: safety, systemic spread, and antitumor activity.
Molecular therapy : the journal of the American Society of Gene Therapy · 2015-01 · Zeh HJ, Downs-Canner S, McCart JA 외 16
- [Effects of carbonated water intake on constipation in elderly patients following a cerebrovascular accident].
Journal of Korean Academy of Nursing · 2011-04 · Mun JH, Jun SS
Patents
KIPRIS · applicant-matchedUS · Published · 2024-06 · Application 18738887
PCT · Published · 2023-09 · Application PCT/KR2023/013363
CN · Published · 2023-09 · Application 202380064071.5
US · Published · 2023-09 · Application 19108937
EP · Published · 2023-09 · Application 23863505.6
Registered · 2023-09 · Application 1020230118519
CN · Published · 2023-03 · Application 202380024317.6
US · Published · 2023-03 · Application 18841770
EP · Published · 2023-03 · Application 23763747.5
PCT · Published · 2023-03 · Application PCT/KR2023/002954
Show 81 more patents
Published · 2023-03 · Application 1020247029599
US · Published · 2023-02 · Application 18163015
CN · Published · 2022-12 · Application 202280089806.5
CN · Published · 2022-12 · Application 202280089797.X
CN · Published · 2022-12 · Application 202280089807.X
PCT · Published · 2022-12 · Application PCT/KR2022/020390
US · Published · 2022-12 · Application 18717562
US · Published · 2022-12 · Application 18717567
US · Published · 2022-12 · Application 18717589
EP · Published · 2022-12 · Application 22907944.7
EP · Published · 2022-12 · Application 22907945.4
EP · Published · 2022-12 · Application 22907946.2
PCT · Published · 2022-12 · Application PCT/KR2022/020392
PCT · Published · 2022-12 · Application PCT/KR2022/020393
Published · 2022-12 · Application 1020247019967
Published · 2022-12 · Application 1020247019965
Published · 2022-12 · Application 1020247019966
CN · Published · 2022-07 · Application 202280097554.0
PCT · Published · 2022-07 · Application PCT/KR2022/009910
US · Published · 2022-07 · Application 18879477
EP · Published · 2022-07 · Application 22949543.7
Registered · 2022-06 · Application 1020220080056
CN · Published · 2022-02 · Application 202280017268.9
PCT · Published · 2022-02 · Application PCT/KR2022/002805
US · Published · 2022-02 · Application 18278879
EP · Published · 2022-02 · Application 22760122.6
Registered · 2022-02 · Application 1020220025274
- Subsidiary: SillaJen Biotherapeutics, Inc.ONCOLYTIC VACCINIA VIRUS CANCER THERAPY
US · Published · 2021-03 · Application 17200725
US · Published · 2020-09 · Application 17761932
PCT · Published · 2020-09 · Application PCT/US2020/052222
- Subsidiary: SillaJen Biotherapeutics, Inc.ONCOLYTIC VACCINIA VIRUS CANCER THERAPY
US · Published · 2019-09 · Application 16577966
Registered · 2019-09 · Application 1020190111125
Rejected · 2019-08 · Application 1020190094159
Withdrawn · 2019-02 · Application 1020190019236
- Subsidiary: SillaJen Biotherapeutics, Inc.Methods and compositions for production of vaccina virus
US · Registered · 2019-02 · Application 16270585
PCT · Published · 2019-02 · Application PCT/KR2019/001480
CN · Published · 2018-04 · Application 202410629808.X
CN · Published · 2018-04 · Application 201880035158.9
US · Published · 2018-04 · Application 16606681
EP · Published · 2018-04 · Application 23205199.5
EP · Registered · 2018-04 · Application 18723290.5
PCT · Published · 2018-04 · Application PCT/US2018/028952
Published · 2018-04 · Application 1020247026223
Rejected · 2018-04 · Application 1020197034430
US · Registered · 2018-02 · Application 15892247
- Subsidiary: SillaJen Biotherapeutics, Inc.ONCOLYTIC VACCINIA VIRUS CANCER THERAPY
US · Published · 2018-02 · Application 15892265
- Subsidiary: SillaJen Biotherapeutics, Inc.Methods and compositions for production of vaccinia virus
US · Registered · 2017-06 · Application 15634765
CN · Published · 2016-09 · Application 201680064990.2
US · Registered · 2016-09 · Application 15758689
EP · Published · 2016-09 · Application 16844635.9
PCT · Published · 2016-09 · Application PCT/KR2016/009866
Registered · 2016-09 · Application 1020187009770
CN · Published · 2016-06 · Application 201680048316.5
US · Registered · 2016-06 · Application 15738034
EP · Registered · 2016-06 · Application 16840890.4
PCT · Published · 2016-06 · Application PCT/IB2016/000993
Registered · 2016-06 · Application 1020187001688
- Subsidiary: SillaJen Biotherapeutics, Inc.Oncolytic vaccinia virus cancer therapy
US · Registered · 2015-12 · Application 14966691
Rejected · 2015-11 · Application 1020150156810
- Subsidiary: SillaJen Biotherapeutics, Inc.Systemic treatment of metastatic and/or systemically-disseminated cancers using GM-CSF-expressing poxviruses
US · Registered · 2015-10 · Application 14876195
- Subsidiary: SillaJen Biotherapeutics, Inc.Oncolytic vaccinia virus cancer therapy
US · Registered · 2015-03 · Application 14656397
- Subsidiary: SillaJen Biotherapeutics, Inc.Oncolytic vaccinia virus combination cancer therapy
US · Registered · 2014-05 · Application 14273476
Registered · 2014-04 · Application 1020140043169
Withdrawn · 2013-04 · Application 1020130039502
Withdrawn · 2013-04 · Application 1020130039506
Withdrawn · 2013-04 · Application 1020130039499
- Subsidiary: SillaJen Biotherapeutics, Inc.METHODS AND COMPOSITIONS FOR PRODUCTION OF VACCINA VIRUS
EP · Registered · 2012-08 · Application 12746243.0
Registered · 2012-08 · Application 1020147005901
EP · Registered · 2012-01 · Application 12732263.4
Registered · 2012-01 · Application 1020137020612
- Subsidiary: SillaJen Biotherapeutics, Inc.Oncolytic vaccinia virus combination cancer therapy
CN · Published · 2010-09 · Application 201710457965.7
- Subsidiary: SillaJen Biotherapeutics, Inc.ONCOLYTIC VACCINIA VIRUS COMBINATION CANCER THERAPY
EP · Registered · 2010-09 · Application 18166620.7
- Subsidiary: SillaJen Biotherapeutics, Inc.ONCOLYTIC VACCINIA VIRUS COMBINATION CANCER THERAPY
EP · Registered · 2010-09 · Application 10816293.4
Registered · 2010-09 · Application 1020177019328
Expired · 2010-09 · Application 1020127009426
- Subsidiary: SillaJen Biotherapeutics, Inc.ONCOLYTIC VACCINIA VIRUS CANCER THERAPY
EP · Registered · 2008-03 · Application 08732358.0
Registered · 2008-03 · Application 1020157008176
Rejected · 2008-03 · Application 1020097021555
Registered · 2006-09 · Application 1020147006129
Rejected · 2006-09 · Application 1020087008408
Rejected · 2003-08 · Application 1020137001466
AI reads
MAA server logs · IP-verifiedPulled records become part of each AI's index and keep feeding its answers. When an AI cites from that index, nothing reaches our server — so actual citations are uncounted here and exceed this number.
Times an AI needed something not yet in its index and fetched this page fresh while answering. Citations served from the index leave no trace here.
Collected as raw material for future answers.
Queries from users who connected this index to their own AI.
- OpenAIChatGPT-Userlive1
- OpenAIOAI-SearchBot176
- GoogleGoogleOther45
- PerplexityPerplexityBot11
- AnthropicClaudeBot2
- MicrosoftBingbot1
Measured since Aug 27, 2026 · 5 AI engines · last read Oct 8, 2026
User-agent strings can be forged, so we do not count them at face value. We count only requests matched against vendor-published IP ranges, or confirmed by forward-verified reverse DNS. MCP queries are actual calls to this index's tool endpoint.
Connect this company index directly to your AI
Connect it to ChatGPT or Claude, and your AI queries the full record — profiles, financials, stock data, regulatory approvals, clinical trials, publications and patents — for SillaJen, Inc. and every listed Korean medical, bio and AI company.
How to connect (MCP)Companies in the same categoryBiotech & Drug Discovery
KOSDAQ-listed integrated security company behind the V3 antivirus and AhnLab TrusGuard and XDR solutions.
Drug delivery system company behind the long-acting injectable platform IVL-DrugFluidic and the LNP delivery platform IVL-GeneFluidic.
Organoid-based biotech founded 2018, KOSDAQ-listed 2025, developing the ATORM-C regenerative therapeutic and ODISEI evaluation solution.
EDGC, a Korea-US joint venture of Eone Medical Foundation and Diagnomics, offers the NIPT service NICE and liquid biopsy OncoCatch.
A diversified SK group company operating eco-friendly chemical materials alongside pharmaceutical products like Joins and vaccines through subsidiary SK Bioscience.
Genomics and drug developer behind the osteoarthritis drug Acelex and the AI-driven healthcare platform Invites Loop.
KOSDAQ-listed antibody biotech developing the next-generation immuno-oncology candidate Multi-AbKine on its fully human antibody library Ymax®-ABL.
A holding company overseeing 54 affiliates including its main biopharmaceutical subsidiary GC, with no direct product manufacturing of its own.
Founded in 2015 and listed on KOSPI in 2021, Prestige BioPharma develops antibody biosimilars and novel antibody drugs including Tuznue.
KOSDAQ-listed biotech company developing molecular diagnostics with proprietary C-Tag technology and the NeoPlex product line.
A vaccine specialist developing in-house products such as SKYCellflu and SKYZoster while also serving as CDMO for AstraZeneca and Novavax.
Medipost, founded in 2000 and KOSDAQ-listed in 2005, specializes in cord blood banking and stem cell therapeutics.
Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
- Company basics
- Korea Exchange · DART
- Business content
- Compiled from disclosure filings
- Approvals & clinical trials
- Korean MFDS (data.go.kr) · US FDA openFDA — updated weekly
- Key disclosures
- KRX KIND via OpenDART exchange filings — updated daily
- Global clinical trials
- ClinicalTrials.gov (US NIH) — sponsor-matched, updated weekly
- Financials
- DART corporate disclosure filings — annual
- Publications
- PubMed (US National Library of Medicine) — affiliation-matched, updated daily
- Patents
- KIPRIS (Korea Institute of Patent Information) — applicant-matched, updated monthly
- AI reads
- Our server logs, IP-verified every 6 hours
- AI visibility
- Measured 2026-10-01
This page is compiled from public sources without the company's involvement. If anything is inaccurate or incomplete, please let us know. Materials provided by the company are labelled as such.
Request a correction or addition