MedPacto, Inc.
Oncology drug developer spun off from Theragen Etex, advancing TGF-β inhibitor Vactosertib as its lead pipeline candidate.
As of 2026-10-10, MedPacto, Inc. has 51 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
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Business overview
Source: DART corporate disclosureSpun off from Theragen Etex's drug discovery institute, MedPacto was founded in 2013 and listed on KOSDAQ in 2019 as an oncology drug development company. Its lead pipeline is the TGF-β inhibitor Vactosertib, alongside follow-on candidates MP010, a tumor-microenvironment-targeting fusion protein, and MP2021 for bone and autoimmune diseases. Vactosertib is in Phase 1/2 as monotherapy for osteosarcoma and Phase 2b/3 in combination with pembrolizumab for colorectal cancer in the US and Korea, under co-development agreements with AstraZeneca's Imfinzi and MSD's Keytruda.
Clinical trials
data.go.kr7 MFDS clinical trial authorisations · 2018–2023 (Phase 1 2 · Phase 2 2 · Phase 1/2a 2 · Phase 1/2 1)
- Phase 1/2백토서팁(TEW-7197)2023-02-15
6 trial sites
- Phase 1백토서팁(TEW-7197)2023-02-14
2 trial sites
- Phase 2백토서팁(TEW-7197)2021-11-23
6 trial sites
- Phase 2백토서팁(TEW-7197)2020-08-06
10 trial sites
- Phase 1/2a백토서팁(TEW-7197)2018-10-01
4 trial sites
- Phase 1/2a백토서팁(TEW-7197)2018-09-07
5 trial sites
- Phase 1백토서팁(TEW-7197)2018-06-18
1 trial site
Global clinical trials
ClinicalTrials.gov · sponsor-matchedPhase 1/2 · Recruiting · 2023-05 · NCT05588648
Phase 2 · Withdrawn · 2021-06 · NCT06219733
Phase 2 · Terminated · 2020-12 · NCT04515979
Phase 2 · Withdrawn · 2019-12 · NCT04064190
Phase 1/2 · Completed · 2019-02 · NCT03732274
Phase 1/2 · Completed · 2018-12 · NCT03724851
Phase 1/2 · Completed · 2018-08 · NCT03698825
Phase 1 · Completed · 2018-08 · NCT03704675
Phase 1 · Completed · 2018-01 · NCT03074006
Phase 1 · Completed · 2014-07 · NCT02160106
R&D and key agreements
Source: DART corporate disclosure백토서팁 (Vactosertib) · 골육종 · 1/2상 · Monotherapy, US and Korea
백토서팁 (Vactosertib) · 대장암 · 2b/3상 · Combination with pembrolizumab (Keytruda), US and Korea
MP010 · 난치성 고형암 · 전임상 · Recombinant fusion protein targeting tumor microenvironment
MP2021 · 골다공증, 류마티스관절염, 뼈 전이 · 전임상 · Targets TM4SF19
Key disclosures
KRX KIND via OpenDARTShow 1 more events
Publications
PubMed · affiliation-matched- ESRP1-regulated DNMT3B isoform switching determines the malignant potential of pancreatic cancer.
Oncogene · 2026-09 · Hong E, Park H, Kim J 외 20
- The Dendritic Cell-based Vaccine PROTEXI leverages Antiviral CD4 T cell Memory to boost anti-tumor immune responses in mice.
Nature communications · 2026-07 · Kang JM, Han EH, Choi JK 외 6
- Vactosertib plus pembrolizumab in patients with non-microsatellite instability-high metastatic colorectal or gastric cancer: a multicenter, phase Ib/IIa study.
Nature communications · 2026-07 · Lee KW, Park YS, Ahn JB 외 12
- Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis.
Nature communications · 2026-05 · Aluri S, Bachiashvili K, Budhathoki A 외 30
- Tm4sf19 inhibition alleviates imiquimod-induced psoriatic dermatitis by regulating inflammatory signaling pathways and keratinocyte proliferation in mice.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026-04 · Kang MG, Park S, Hong E 외 17
- Tm4sf19 inhibition ameliorates inflammation and bone destruction in collagen-induced arthritis by suppressing TLR4-mediated inflammatory signaling and abnormal osteoclast activation.
Bone research · 2025-03 · Park S, Yoon K, Hong E 외 19
- Chlorhexidine Dihydrochloride Shows Anti-tumor Effects in Desmoid Tumors and Colorectal Cancer.
Anticancer research · 2024-12 · Shin H, Kim Y, Lee Y 외 5
- Anti-tumor Effects of Idarubicin Hydrochloride in Desmoid Tumors.
Anticancer research · 2024-12 · Lee Y, Kim Y, Shin H 외 4
- The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial.
Nature communications · 2024-08 · Malek E, Rana PS, Swamydas M 외 7
- Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity.
Cancer communications (London, England) · 2024-08 · Choi SH, Myers JT, Tomchuck SL 외 7
Show 41 more publications
- MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
Experimental & molecular medicine · 2024-07 · Lee DJ, Kim P, Kim HY 외 10
- Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
Metabolism: clinical and experimental · 2024-02 · Park S, Heo JS, Mizuno S 외 26
- Pellino 3 promotes the colitis-associated colorectal cancer through suppression of IRF4-mediated negative regulation of TLR4 signalling.
Molecular oncology · 2023-11 · Kim YM, Kim HY, Ha Thi HT 외 4
- N-linked glycosylation is essential for anti-tumor activities of KIAA1324 in gastric cancer.
Cell death & disease · 2023-08 · Yun R, Hong E, Kim J 외 7
- Vactosertib, a novel TGF-β1 type I receptor kinase inhibitor, improves T-cell fitness: a single-arm, phase 1b trial in relapsed/refractory multiple myeloma.
Research square · 2023-07 · Malek E, Rana PS, Swamydas M 외 7
- Effect of aging on the formation and growth of colonic epithelial organoids by changes in cell cycle arrest through TGF-β-Smad3 signaling.
Inflammation and regeneration · 2023-07 · Jo MK, Moon CM, Jeon HJ 외 8
- Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation.
Experimental & molecular medicine · 2023-06 · Lee J, Ha J, Kim JH 외 15
- MAST4 controls cell cycle in spermatogonial stem cells.
Cell proliferation · 2023-04 · Lee SJ, Kim KH, Lee DJ 외 4
- Oral TGF-βR1 inhibitor Vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity.
Research square · 2023-04 · Choi SH, Myers J, Tomchuck S 외 7
- Combination treatment of T1-44, a PRMT5 inhibitor with Vactosertib, an inhibitor of TGF-β signaling, inhibits invasion and prolongs survival in a mouse model of pancreatic tumors.
Cell death & disease · 2023-02 · Hong E, Barczak W, Park S 외 10
- Therapeutic Implications of TGF-β Pathway in Desmoid Tumor Based on Comprehensive Molecular Profiling and Clinicopathological Properties.
Cancers · 2022-12 · Yun KH, Park C, Ryu HJ 외 11
- ESRP1-regulated isoform switching of LRRFIP2 determines metastasis of gastric cancer.
Nature communications · 2022-10 · Lee J, Pang K, Kim J 외 12
- Mast4 determines the cell fate of MSCs for bone and cartilage development.
Nature communications · 2022-07 · Kim P, Park J, Lee DJ 외 21
- Wasting condition as a marker for severe disease in pediatric Crohn's disease.
Medicine · 2022-05 · Jin W, Yang DH, Tchah H 외 4
- Amelioration of cancer cachexia with preemptive administration of tumor necrosis factor-α blocker.
Journal of clinical biochemistry and nutrition · 2022-03 · Kang EA, Park JM, Jin W 외 3
- Degradation of DRAK1 by CUL3/SPOP E3 Ubiquitin ligase promotes tumor growth of paclitaxel-resistant cervical cancer cells.
Cell death & disease · 2022-02 · Pang K, Lee J, Kim J 외 12
- Therapeutic effects of placenta derived-, umbilical cord derived-, and adipose tissue derived-mesenchymal stem cells in chronic Helicobacter pylori infection: comparison and novel mechanisms.
Journal of clinical biochemistry and nutrition · 2021-09 · Park JM, Han YM, Hwang SJ 외 2
- Penetration Cascade of Size Switchable Nanosystem in Desmoplastic Stroma for Improved Pancreatic Cancer Therapy.
ACS nano · 2021-09 · Zhao X, Yang X, Wang X 외 7
- Metastasis Risk Assessment Using BAG2 Expression by Cancer-Associated Fibroblast and Tumor Cells in Patients with Breast Cancer.
Cancers · 2021-09 · Yoon CI, Ahn SG, Cha YJ 외 8
- Transcriptome profiling implicated in beneficiary actions of kimchi extracts against Helicobacter pylori infection.
Journal of clinical biochemistry and nutrition · 2021-09 · Park JM, Han YM, Oh JY 외 3
- Fermented kimchi rejuvenated precancerous atrophic gastritis via mitigating Helicobacter pylori-associated endoplasmic reticulum and oxidative stress.
Journal of clinical biochemistry and nutrition · 2021-09 · Park JM, Han YM, Oh JY 외 4
- Microbiota changes with fermented kimchi contributed to either the amelioration or rejuvenation of Helicobacter pylori-associated chronic atrophic gastritis.
Journal of clinical biochemistry and nutrition · 2021-07 · Park JM, Lee WH, Seo H 외 4
- Phytochemicals in Cancer Immune Checkpoint Inhibitor Therapy.
Biomolecules · 2021-07 · Lee J, Han Y, Wang W 외 7
- Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
Cell death and differentiation · 2021-05 · Lee SJ, Park J, Lee DJ 외 9
- Transcriptome profiling analysis of the response to walnut polyphenol extract in Helicobacter pylori-infected cells.
Journal of clinical biochemistry and nutrition · 2021-05 · Park JM, Han YM, Lee HJ 외 3
- Fecal microbiota changes with fermented kimchi intake regulated either formation or advancement of colon adenoma.
Journal of clinical biochemistry and nutrition · 2021-03 · Park JM, Lee WH, Seo H 외 4
- Tetraarsenic hexoxide enhances generation of mitochondrial ROS to promote pyroptosis by inducing the activation of caspase-3/GSDME in triple-negative breast cancer cells.
Cell death & disease · 2021-02 · An H, Heo JS, Kim P 외 15
- Dietary intake of walnut prevented Helicobacter pylori-associated gastric cancer through rejuvenation of chronic atrophic gastritis.
Journal of clinical biochemistry and nutrition · 2021-01 · Park JM, Han YM, Park YJ 외 1
- Rejuvenation of Helicobacter pylori-Associated Atrophic Gastritis Through Concerted Actions of Placenta-Derived Mesenchymal Stem Cells Prevented Gastric Cancer.
Frontiers in pharmacology · 2021-01 · Park JM, Han YM, Hahm KB
- Nicotinamide Riboside Vitamin B3 Mitigated C26 Adenocarcinoma-Induced Cancer Cachexia.
Frontiers in pharmacology · 2021-01 · Park JM, Han YM, Lee HJ 외 2
- Revaprazan prevented indomethacin-induced intestinal damages by enhancing tight junction related mechanisms.
Biochemical pharmacology · 2020-12 · Han YM, Park JM, Her S 외 3
- ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer.
Antioxidants (Basel, Switzerland) · 2020-11 · Wang W, Im J, Kim S 외 6
- Walnut polyphenol extracts inhibit Helicobacter pylori-induced STAT3Tyr705 phosphorylation through activation of PPAR-γ and SOCS1 induction.
Journal of clinical biochemistry and nutrition · 2020-11 · Park JM, An JM, Han YM 외 4
- Dietary intake of fermented kimchi prevented colitis-associated cancer.
Journal of clinical biochemistry and nutrition · 2020-11 · Han YM, A Kang E, Min Park J 외 4
- 5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation.
Nature communications · 2020-10 · Cho YH, Ro EJ, Yoon JS 외 6
- The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications · 2020-09 · Naka K, Ochiai R, Matsubara E 외 11
- Pharmacokinetic characteristics of vactosertib, a new activin receptor-like kinase 5 inhibitor, in patients with advanced solid tumors in a first-in-human phase 1 study.
Investigational new drugs · 2020-06 · Jung SY, Hwang S, Clarke JM 외 6
- Small molecule-induced simultaneous destabilization of β-catenin and RAS is an effective molecular strategy to suppress stemness of colorectal cancer cells.
Cell communication and signaling : CCS · 2020-03 · Cho YH, Ro EJ, Yoon JS 외 5
- Inhibition of TGF-β signalling in combination with nal-IRI plus 5-Fluorouracil/Leucovorin suppresses invasion and prolongs survival in pancreatic tumour mouse models.
Scientific reports · 2020-02 · Hong E, Park S, Ooshima A 외 9
- Population pharmacokinetics of vactosertib, a new TGF-β receptor type Ι inhibitor, in patients with advanced solid tumors.
Cancer chemotherapy and pharmacology · 2020-01 · Jung SY, Yug JS, Clarke JM 외 6
- Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2017-12 · Kang DW, Lee BH, Suh YA 외 5
Patents
KIPRIS · applicant-matchedPCT · Published · 2025-09 · Application PCT/KR2025/014051
Published · 2025-07 · Application 1020250101534
Published · 2024-11 · Application 1020240169417
PCT · Published · 2024-11 · Application PCT/KR2024/018743
Published · 2024-09 · Application 1020240124012
Rejected · 2023-08 · Application 1020230107624
PCT · Published · 2023-08 · Application PCT/KR2023/012184
CN · Published · 2023-03 · Application 202310291285.8
US · Registered · 2023-03 · Application 18188912
US · Published · 2023-01 · Application 18155530
Show 52 more patents
CN · Published · 2022-06 · Application 202280038803.9
EP · Published · 2022-06 · Application 22816502.3
PCT · Published · 2022-06 · Application PCT/KR2022/007939
Registered · 2022-06 · Application 1020220068347
Registered · 2022-03 · Application 1020220037241
Withdrawn · 2020-10 · Application 1020200138600
CN · Published · 2020-02 · Application 202080028383.7
US · Registered · 2020-02 · Application 16758934
US · Registered · 2020-02 · Application 16758930
EP · Published · 2020-02 · Application 20755277.9
EP · Published · 2020-02 · Application 20755764.6
PCT · Published · 2020-02 · Application PCT/IB2020/051136
PCT · Published · 2020-02 · Application PCT/IB2020/051139
US · Published · 2019-06 · Application 17255432
CN · Published · 2019-06 · Application 201980043404.X
EP · Published · 2019-06 · Application 19824936.9
PCT · Published · 2019-06 · Application PCT/IB2019/055475
Rejected · 2019-06 · Application 1020217002540
US · Registered · 2019-02 · Application 16279733
Registered · 2019-02 · Application 1020190016347
Registered · 2019-02 · Application 1020190016359
CN · Published · 2018-10 · Application 201880069653.1
US · Published · 2018-10 · Application 16758928
EP · Registered · 2018-10 · Application 18871731.8
PCT · Published · 2018-10 · Application PCT/KR2018/012591
Registered · 2017-10 · Application 1020170139244
Registered · 2017-10 · Application 1020170138455
Registered · 2017-03 · Application 1020170027775
CN · Published · 2016-04 · Application 201680009490.9
US · Registered · 2016-04 · Application 15549513
EP · Registered · 2016-04 · Application 20177845.3
EP · Registered · 2016-04 · Application 16776857.1
PCT · Published · 2016-04 · Application PCT/KR2016/003602
CN · Published · 2016-02 · Application 201680008852.2
US · Registered · 2016-02 · Application 15548580
PCT · Published · 2016-02 · Application PCT/KR2016/001175
Expired · 2016-02 · Application 1020160013547
PCT · Published · 2016-01 · Application PCT/KR2016/000987
Registered · 2016-01 · Application 1020160011878
CN · Published · 2016-01 · Application 201680008966.7
US · Published · 2016-01 · Application 15548587
EP · Registered · 2016-01 · Application 16746769.5
PCT · Published · 2016-01 · Application PCT/KR2016/000647
Registered · 2016-01 · Application 1020197013763
Withdrawn · 2016-01 · Application 1020177019696
US · Published · 2015-11 · Application 14933607
Rejected · 2015-07 · Application 1020150106779
PCT · Published · 2013-12 · Application PCT/KR2013/012370
Withdrawn · 2012-12 · Application 1020120158533
US · Registered · 2012-12 · Application 13730423
EP · Registered · 2011-11 · Application 11844745.7
Registered · 2011-11 · Application 1020110124360
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Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
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