Helixmith Co., Ltd
A biotech R&D company developing cell and gene therapies such as VM202 alongside natural-product-derived new drugs.
As of 2026-10-10, Helixmith Co., Ltd has 25 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
Price
Change
Market cap
Business overview
Source: DART corporate disclosureFounded in 1996 and listed on KOSDAQ in 2005, Helixmith is a biotech company focused on new drug R&D. Its pipeline includes the cell and gene therapy VM202 (diabetic foot ulcer, critical limb ischemia, ALS, CMT), NM301 (ALS), CX801 (colorectal cancer), CX804 (ovarian cancer), and VM507 (kidney disease), while natural-product ingredients PG102, HX106, and HX107 have received individual-type functional food ingredient recognition and are used in its health functional food and cosmetics B2B business. VM202's U.S. Phase 3 trial was terminated early while its China Phase 3 trial was completed and is pursuing marketing approval; the ALS indication completed U.S./Korea Phase 2 and the CMT indication completed Korea Phase 1, and a research team of 16 (4 PhDs, 11 master's-level researchers) has conducted government R&D projects since 1999.
Products & technology
- PG102Improvement of immune hypersensitivity reactions
- HX106Memory improvement
- HX107Suppression of postprandial blood glucose rise
Clinical trials
data.go.kr5 MFDS clinical trial authorisations · 2012–2022 (Phase 2a 2 · Phase 2 2 · Phase 1/2a 1)
- Phase 2a엔젠시스(Engensis),VM2022022-04-18
1 trial site
- Phase 2a엔젠시스(Engensis),VM2022021-06-16
1 trial site
- Phase 1/2a엔젠시스(Engensis),VM2022020-04-20
1 trial site
- Phase 2엔젠시스(Engensis),VM2022016-07-29
3 trial sites
- Phase 2엔젠시스(Engensis),VM2022012-04-02
4 trial sites
Global clinical trials
ClinicalTrials.gov · sponsor-matchedPhase 2 · Completed · 2021-11 · NCT05176093
Phase 3 · Completed · 2021-05 · NCT04873232
Phase 2/3 · Withdrawn · 2021-05 · NCT05552625
Phase 2 · Completed · 2021-03 · NCT04632225
Phase 3 · Completed · 2020-11 · NCT04469270
Phase 1/2 · Completed · 2020-09 · NCT05361031
Phase 3 · Completed · 2019-02 · NCT04055090
Phase 2 · Withdrawn · 2018-01 · NCT03404024
Phase 3 · Terminated · 2017-06 · NCT02563522
Phase 3 · Completed · 2016-04 · NCT02427464
Show 9 more trials
Phase 1/2 · Withdrawn · 2015-03 · NCT01002495
Phase 1/2 · Completed · 2014-03 · NCT02039401
Phase 2 · Completed · 2012-08 · NCT01475786
Phase 2 · Completed · 2010-07 · NCT01064440
Phase 1/2 · Completed · 2010-02 · NCT01002235
Phase 1 · Completed · 2007-04 · NCT00696124
Phase 1/2 · Completed · 2007-01 · NCT01422772
Phase 1/2 · Withdrawn · 2007-01 · NCT00778882
Phase 2 · Withdrawn · 2006-12 · NCT01122485
R&D and key agreements
Source: DART corporate disclosureVM202 · 당뇨병성 허혈성 족부궤양(PAD/NHU), 중증하지허혈(PAD/CLI) · 미국 임상 3상 조기 종료 / 중국 임상 3상 완료·시판허가 진행 · Plasmid DNA-based cell and gene therapy pipeline
VM202 · 근위축성 측삭경화증(ALS, 루게릭병) · 미국/한국 임상 2상 완료
VM202 · 샤르코-마리-투스병(CMT) · 한국 임상 1상 완료
NM301 · 근위축성 측삭경화증(ALS) · 후보물질 발굴 혹은 전임상
CX801 · 대장암 · 전임상
CX804 · 난소암 · 전임상
VM507 · 신장질환 · 전임상
Key disclosures
KRX KIND via OpenDARTPublications
PubMed · affiliation-matched- CD28-ICOS costimulation enhances the therapeutic efficacy of L1CAM-targeted CAR-T cells against ovarian and gastric cancers.
Journal for immunotherapy of cancer · 2026-09 · Che X, Yun UJ, Lee J 외 13
- A Tetrameric Biotin-Avidin Scaffold Using Anti-CD19 (FMC63) Traptavidin Fusion Enables High-Avidity CAR-T Cells for Leukemia Therapy.
Bioconjugate chemistry · 2026-01 · Ko HL, Kim YY, Lee DK 외 8
- The Modulation of Fibrosis in Vocal Fold Repair: A Study on c-Met Agonistic Antibodies and Hepatocyte Growth in Animal Studies.
Medicina (Kaunas, Lithuania) · 2024-12 · Shin HI, Choi H, Jung JK 외 1
- A mixture of Pueraria lobata and Platycodon grandiflorum extracts ameliorates RANKL-induced osteoclast differentiation and ovariectomy-induced bone loss by regulating Src- PI3K-AKT and JNK/p38 signaling pathways.
Heliyon · 2024-01 · Song J, Han S, Choi S 외 7
- Botanical formulation HX110B ameliorates PPE-induced emphysema in mice via regulation of PPAR/RXR signaling pathway.
PloS one · 2024-01 · Lee S, Lee CH, Lee J 외 10
- Novel rAAV vector mediated intrathecal HGF delivery has an impact on neuroimmune modulation in the ALS motor cortex with TDP-43 pathology.
Gene therapy · 2023-08 · Genç B, Nho B, Seung H 외 12
- Construction of Plasmid DNA Expressing Two Isoforms of Insulin-Like Growth Factor-1 and Its Effects on Skeletal Muscle Injury Models.
Human gene therapy · 2022-12 · Lee J, Ko KR, Lee N 외 4
- Therapeutic Effects of Acer palmatum Thumb. Leaf Extract (KIOM-2015E) on Benzalkonium Chloride-Induced Dry Eye in a Mouse Model.
International journal of molecular sciences · 2022-11 · Yim NH, Park E, Cho WK 외 2
- Gabapentin inhibits the analgesic effects and nerve regeneration process induced by hepatocyte growth factor (HGF) in a peripheral nerve injury model: Implication for the use of VM202 and gabapentinoids for peripheral neuropathy.
Molecular and cellular neurosciences · 2022-09 · Lee N, Nho B, Ko KR 외 2
- The Regenerative Effects of c-Met Agonistic Antibodies in Vocal Fold Atrophy.
International journal of molecular sciences · 2022-07 · Choi H, Yu SS, Choi J 외 1
Show 15 more publications
- Efficacy and safety of Gyejibokryeong-hwan (GBH) in major depressive disorder: study protocol for multicentre randomised controlled trial.
Trials · 2022-06 · Choi Y, Jung IC, Kim JY 외 9
- Intramuscular injection of a plasmid DNA vector expressing hepatocyte growth factor (HGF) ameliorated pain symptoms by controlling the expression of pro-inflammatory cytokines in the dorsal root ganglion.
Biochemical and biophysical research communications · 2022-06 · Nho B, Ko KR, Kim S 외 1
- Hepatocyte growth factor is necessary for efficient outgrowth of injured peripheral axons in in vitro culture system and in vivo nerve crush mouse model.
Biochemistry and biophysics reports · 2021-07 · Lee N, Lee SH, Lee J 외 4
- cMet agonistic antibody prevents acute kidney injury to chronic kidney disease transition by suppressing Smurf1 and activating Smad7.
Clinical science (London, England : 1979) · 2021-06 · Li L, Lee J, Cho A 외 12
- Gene therapy for diabetic peripheral neuropathy: A randomized, placebo-controlled phase III study of VM202, a plasmid DNA encoding human hepatocyte growth factor.
Clinical and translational science · 2021-05 · Kessler JA, Shaibani A, Sang CN 외 4
- Hepatocyte growth factor induces pErk and pSTAT3 (Ser 727) to promote mitochondrial activity and neurite outgrowth in primary dorsal root ganglion cultures.
Neuroreport · 2021-04 · Lee N, Lee MY, Lee J 외 4
- Botanical formulation, TADIOS, alleviates lipopolysaccharide (LPS)-Induced acute lung injury in mice via modulation of the Nrf2-HO-1 signaling pathway.
Journal of ethnopharmacology · 2021-04 · Lee W, Lee CH, Lee J 외 10
- Urinary cMet as a prognostic marker in immunoglobulin A nephropathy.
Journal of cellular and molecular medicine · 2020-10 · An JN, Li L, Lee J 외 11
- Botanical preparation HX109 inhibits macrophage-mediated activation of prostate epithelial cells through the CCL4-STAT3 pathway: implication for the mechanism underlying HX109 suppression of prostate hyperplasia.
Heliyon · 2020-06 · Lim S, Kim HK, Lee W 외 1
- cMet agonistic antibody attenuates apoptosis in ischaemia-reperfusion-induced kidney injury.
Journal of cellular and molecular medicine · 2020-05 · An JN, Li L, Lee J 외 10
- Lentivirus-Mediated VEGF Knockdown Suppresses Gastric Cancer Cell Proliferation and Tumor Growth in vitro and in vivo.
OncoTargets and therapy · 2020-01 · Park JH, Seo JH, Jeon HY 외 5
- Intramuscular delivery of HGF-expressing recombinant AAV improves muscle integrity and alleviates neurological symptoms in the nerve crush and SOD1-G93A transgenic mouse models.
Biochemical and biophysical research communications · 2019-09 · Lee SH, Lee N, Kim S 외 5
- Renoprotective effects of a novel cMet agonistic antibody on kidney fibrosis.
Scientific reports · 2019-09 · Kim YC, Lee J, An JN 외 13
- Water-Soluble Extract from Actinidia arguta (Siebold & Zucc.) Planch. ex Miq. and Perilla frutescens (L.) Britton, ACTPER, Ameliorates a Dry Skin-Induced Itch in a Mice Model and Promotes Filaggrin Expression by Activating the AhR Signaling in HaCaT Cells.
Nutrients · 2019-06 · Lee W, Jeong Y, Park JH 외 8
- Intrathecal delivery of recombinant AAV1 encoding hepatocyte growth factor improves motor functions and protects neuromuscular system in the nerve crush and SOD1-G93A transgenic mouse models.
Acta neuropathologica communications · 2019-06 · Lee SH, Kim S, Lee N 외 4
Patents
KIPRIS · applicant-matchedPCT · Published · 2024-12 · Application PCT/KR2024/020000
PCT · Published · 2024-09 · Application PCT/KR2024/014663
Published · 2023-12 · Application 1020230178938
Published · 2023-09 · Application 1020230129833
Rejected · 2023-08 · Application 1020230108635
CN · Published · 2023-04 · Application 202380036395.8
US · Published · 2023-04 · Application 18859354
EP · Published · 2023-04 · Application 23796711.2
PCT · Published · 2023-04 · Application PCT/KR2023/005447
Withdrawn · 2023-03 · Application 1020230043204
Show 142 more patents
Published · 2023-02 · Application 1020230025370
Rejected · 2023-02 · Application 1020230020361
PCT · Published · 2023-02 · Application PCT/KR2023/002208
US · Published · 2022-12 · Application 18148130
CN · Published · 2022-12 · Application 202280094119.2
US · Published · 2022-12 · Application 18849175
EP · Published · 2022-12 · Application 22933783.7
PCT · Published · 2022-12 · Application PCT/KR2022/019410
Withdrawn · 2022-12 · Application 1020220166135
US · Published · 2022-11 · Application 18054606
Withdrawn · 2022-11 · Application 1020220145631
Withdrawn · 2022-06 · Application 1020220079310
US · Published · 2022-06 · Application 17840602
Published · 2022-04 · Application 1020220052369
Withdrawn · 2022-03 · Application 1020220039189
PCT · Published · 2022-03 · Application PCT/KR2022/004416
US · Published · 2022-01 · Application 17576004
US · Published · 2021-11 · Application 17523740
Published · 2021-10 · Application 1020210139549
PCT · Published · 2021-10 · Application PCT/KR2021/014596
Registered · 2021-06 · Application 1020210073007
Registered · 2021-02 · Application 1020210016246
Rejected · 2021-01 · Application 1020210005996
PCT · Published · 2020-11 · Application PCT/KR2020/017187
PCT · Published · 2020-10 · Application PCT/KR2020/013713
US · Registered · 2020-09 · Application 17763712
EP · Published · 2020-09 · Application 20868836.6
PCT · Published · 2020-09 · Application PCT/KR2020/013127
US · Published · 2020-07 · Application 16940277
CN · Published · 2020-04 · Application 202080032176.9
US · Published · 2020-04 · Application 17604841
EP · Published · 2020-04 · Application 20798407.1
PCT · Published · 2020-04 · Application PCT/KR2020/005475
Registered · 2020-04 · Application 1020200050374
Registered · 2019-12 · Application 1020190175402
US · Published · 2019-12 · Application 16721073
Rejected · 2019-11 · Application 1020190149876
US · Published · 2019-11 · Application 17297097
EP · Published · 2019-11 · Application 19890368.4
PCT · Published · 2019-11 · Application PCT/KR2019/015987
PCT · Published · 2019-11 · Application PCT/KR2019/015988
Registered · 2019-11 · Application 1020190149902
CN · Published · 2019-11 · Application 201980075213.1
US · Registered · 2019-11 · Application 17293703
EP · Published · 2019-11 · Application 19884831.9
PCT · Published · 2019-11 · Application PCT/KR2019/015475
- Subsidiary: 카텍셀 주식회사항-L1CAM 항체 또는 그의 항원결합 단편, 및 이를 포함하는 키메라 항원 수용체
Registered · 2019-10 · Application 1020190130785
CN · Published · 2019-10 · Application 201980068786.1
PCT · Published · 2019-10 · Application PCT/KR2019/013820
Abandoned · 2019-10 · Application 1020190125721
Registered · 2019-10 · Application 1020190124910
Registered · 2019-09 · Application 1020190119148
CN · Published · 2019-07 · Application 201980013146.0
US · Registered · 2019-07 · Application 16517323
EP · Published · 2019-07 · Application 19838143.6
PCT · Published · 2019-07 · Application PCT/US2019/042702
Registered · 2019-07 · Application 1020217005130
CN · Published · 2019-07 · Application 201980047781.0
CN · Published · 2019-07 · Application 201980047529.X
Rejected · 2019-07 · Application 1020217004788
US · Registered · 2019-07 · Application 16513564
US · Published · 2019-07 · Application 16513560
EP · Published · 2019-07 · Application 19872729.9
PCT · Published · 2019-07 · Application PCT/IB2019/000843
PCT · Published · 2019-07 · Application PCT/IB2019/001399
Published · 2019-07 · Application 1020217004797
CN · Published · 2019-05 · Application 201980032948.6
US · Published · 2019-05 · Application 16414115
EP · Published · 2019-05 · Application 19802668.4
PCT · Published · 2019-05 · Application PCT/KR2019/005873
Rejected · 2019-05 · Application 1020207035482
US · Registered · 2019-05 · Application 17054280
PCT · Published · 2019-05 · Application PCT/KR2019/005558
Registered · 2019-05 · Application 1020190054547
US · Registered · 2019-04 · Application 16387587
Rejected · 2019-04 · Application 1020190038040
CN · Published · 2019-03 · Application 201980019846.0
CN · Published · 2019-03 · Application 201980019847.5
US · Registered · 2019-03 · Application 16980983
US · Registered · 2019-03 · Application 16980917
EP · Published · 2019-03 · Application 19768358.4
EP · Published · 2019-03 · Application 19768114.1
PCT · Published · 2019-03 · Application PCT/KR2019/003062
PCT · Published · 2019-03 · Application PCT/KR2019/003056
Registered · 2019-03 · Application 1020190028956
Registered · 2019-03 · Application 1020190028959
Registered · 2019-01 · Application 1020190012080
CN · Published · 2018-12 · Application 201880085076.5
US · Registered · 2018-12 · Application 16956926
EP · Published · 2018-12 · Application 18894300.5
PCT · Published · 2018-12 · Application PCT/KR2018/016937
Registered · 2018-12 · Application 1020180172615
Registered · 2018-12 · Application 1020180164858
CN · Published · 2018-12 · Application 201880078958.9
US · Published · 2018-12 · Application 16770155
EP · Published · 2018-12 · Application 18885618.1
Expired · 2018-12 · Application 1020180156435
Withdrawn · 2018-11 · Application 1020180150900
Registered · 2018-11 · Application 1020180145144
Registered · 2018-11 · Application 1020180140196
CN · Published · 2018-10 · Application 201880068343.8
EP · Published · 2018-10 · Application 18868758.6
Rejected · 2018-10 · Application 1020207014088
Registered · 2017-08 · Application 1020170110892
US · Registered · 2017-07 · Application 15642307
EP · Registered · 2017-02 · Application 17747834.4
Registered · 2017-02 · Application 1020187022615
US · Registered · 2016-08 · Application 15755819
EP · Published · 2016-08 · Application 21217401.5
EP · Registered · 2016-08 · Application 16842821.7
Registered · 2016-08 · Application 1020187008875
US · Registered · 2015-09 · Application 15514244
EP · Registered · 2015-09 · Application 15843739.2
Expired · 2015-09 · Application 1020150136514
Withdrawn · 2015-08 · Application 1020150115598
US · Registered · 2014-10 · Application 15030999
EP · Registered · 2014-10 · Application 14856385.1
Registered · 2014-10 · Application 1020140143377
Rejected · 2013-01 · Application 1020130009419
Registered · 2012-11 · Application 1020120133253
Registered · 2012-03 · Application 1020137026397
Rejected · 2012-03 · Application 1020147011890
Registered · 2012-03 · Application 1020177005260
Expired · 2009-08 · Application 1020117005609
Expired · 2009-06 · Application 1020107028847
Registered · 2009-04 · Application 1020107025147
Registered · 2009-01 · Application 1020107018680
Expired · 2007-10 · Application 1020097007572
Registered · 2006-10 · Application 1020060098633
Registered · 2006-04 · Application 1020077024073
Expired · 2005-04 · Application 1020050028407
Withdrawn · 2004-04 · Application 1020040024326
Expired · 2003-06 · Application 1020030038012
Expired · 2002-03 · Application 1020020015074
Expired · 2002-01 · Application 1020020000409
Expired · 2001-05 · Application 1020010025476
Expired · 2000-09 · Application 1020000053613
Expired · 1999-12 · Application 1020017008324
Withdrawn · 1999-06 · Application 1019990023398
Rejected · 1998-12 · Application 1019980063711
Expired · 1998-05 · Application 1019980018702
Expired · 1997-09 · Application 1019970048095
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A diversified SK group company operating eco-friendly chemical materials alongside pharmaceutical products like Joins and vaccines through subsidiary SK Bioscience.
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KOSDAQ-listed antibody biotech developing the next-generation immuno-oncology candidate Multi-AbKine on its fully human antibody library Ymax®-ABL.
A holding company overseeing 54 affiliates including its main biopharmaceutical subsidiary GC, with no direct product manufacturing of its own.
Founded in 2015 and listed on KOSPI in 2021, Prestige BioPharma develops antibody biosimilars and novel antibody drugs including Tuznue.
KOSDAQ-listed biotech company developing molecular diagnostics with proprietary C-Tag technology and the NeoPlex product line.
SillaJen, Inc., founded in 2006 and listed on KOSDAQ in 2016, develops the oncolytic virus immunotherapy Pexa-Vec.
A vaccine specialist developing in-house products such as SKYCellflu and SKYZoster while also serving as CDMO for AstraZeneca and Novavax.
Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
- Company basics
- Korea Exchange · DART
- Business content
- Compiled from disclosure filings
- Approvals & clinical trials
- Korean MFDS (data.go.kr) · US FDA openFDA — updated weekly
- Key disclosures
- KRX KIND via OpenDART exchange filings — updated daily
- Global clinical trials
- ClinicalTrials.gov (US NIH) — sponsor-matched, updated weekly
- Financials
- DART corporate disclosure filings — annual
- Publications
- PubMed (US National Library of Medicine) — affiliation-matched, updated daily
- Patents
- KIPRIS (Korea Institute of Patent Information) — applicant-matched, updated monthly
- AI reads
- Our server logs, IP-verified every 6 hours
- AI visibility
- Measured 2026-10-01
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