Genome&Company
A drug developer building ADC and immuno-oncology pipelines on its GNOCLE™ platform, alongside microbiome cosmetics and CDMO businesses.
As of 2026-10-10, Genome&Company has 27 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
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Business overview
Source: DART corporate disclosureFounded in 2015 and listed on KOSDAQ in 2020, Genome & Company is a drug development specialist built on its GNOCLE™ platform, advancing ADC and immuno-oncology pipelines targeting novel antigens. Its novel-target immuno-oncology candidate GENA-104 (EP0089) was licensed to UK-based Ellipses Pharma Limited in February 2025, and its novel-target ADC antibody Debio 0633 was licensed to Debiopharm in June 2024, while the company also runs a consumer business through its microbiome skincare brand UIQ and probiotic IMMUNOVA GEN001. It additionally operates a CDMO business through List Biological Laboratories, a US microbiome CDMO acquired in September 2021, with revenue drawn from licensing income, cosmetics sales, and biopharmaceutical contract manufacturing.
Products & technology
- GENA-104 (EP0089)Novel-target (CNTN4) immuno-oncology antibody candidate
- Debio 0633Novel-target antibody for ADC development
- GENA-104 ADCCNTN4-targeting antibody-drug conjugate candidate
- UIQMicrobiome skincare brand containing Cutibiome, Reliefbiome, Rejubiome ingredients
- IMMUNOVA GEN001Medical-grade probiotic based on strain GEN-001
Clinical trials
data.go.kr3 MFDS clinical trial authorisations · 2020–2022 (Phase 2 2 · Phase 1 1)
- Phase 2GEN-0012022-11-07
8 trial sites
- Phase 2GEN-0012021-10-08
5 trial sites
- Phase 1GEN-0012020-11-09
1 trial site
Global clinical trials
ClinicalTrials.gov · sponsor-matchedPhase 1 · Withdrawn · 2024-02 · NCT06235541
Phase 2 · Terminated · 2023-09 · NCT05998447
Phase 2 · Completed · 2022-04 · NCT05419362
- Subsidiary: Scioto Biosciences, Inc.28-Day Daily-dose Crossover Study of the Safety and Tolerability of SB-121 (Lactobacillus Reuteri With Sephadex® and Maltose) in Subjects, Ages 15 to 45 Years, Diagnosed With Autistic Disorder
Phase 1 · Completed · 2021-08 · NCT04944901
Phase 1 · Completed · 2020-10 · NCT04601402
R&D and key agreements
Source: DART corporate disclosureGENA-104(EP0089) · 면역항암(CNTN4 표적) · 라이선시(엘립시스 파마) 임상1상 · IND approved in Korea Jan 2024; published in Science Immunology Oct 2024; presented at AACR 2025
Debio 0633 · ADC(신규타깃) · 디바이오팜 개발 중 · Combined with Debiopharm's proprietary Multilink technology for ADC development
GENA-104 ADC · CNTN4 표적 ADC · 전임상(PDX 평가 중) · Exatecan (Topo1 inhibitor)-conjugated candidate showed antitumor efficacy in mouse CDX model
GENA-120 · 신규타깃(ITGB4) ADC · Source text is truncated mid-sentence; details unavailable
Key disclosures
KRX KIND via OpenDARTPublications
PubMed · affiliation-matched- Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway.
Experimental & molecular medicine · 2026-09 · Kim NE, Cho B, Kim Y 외 21
- Lactobacillus delbrueckii subsp. lactis CKDB001 Ameliorates Scopolamine-Induced Cognitive Impairment Through Metabolic Modulation.
International journal of molecular sciences · 2025-12 · Kim H, Kim H, Lee Y 외 7
- Functional Expansion of the Skin Microbiome: A Pantothenate-Producing Rothia Strain Confers Anti-Inflammatory and Photoaging-Protective Effects.
International journal of molecular sciences · 2025-12 · Kim HB, Kim G, Park E 외 6
- Corrigendum to "Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation" [Brain Behav. Immun. 122 (2024) 568-582].
Brain, behavior, and immunity · 2025-07 · Kim H, Lee E, Park M 외 16
- Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation.
Brain, behavior, and immunity · 2024-11 · Kim H, Lee E, Park M 외 16
- Contactin-4 suppresses antitumor T cell responses by engaging amyloid precursor protein.
Science immunology · 2024-10 · Jeon BN, Kim S, Kim Y 외 10
- Differential Urinary Microbiome and Its Metabolic Footprint in Bladder Cancer Patients Following BCG Treatment.
International journal of molecular sciences · 2024-10 · Min K, Zheng CM, Kim S 외 12
- Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor.
Cell host & microbe · 2024-08 · Kim Y, Kim G, Kim S 외 17
- Predicting septic shock in obstructive pyelonephritis associated with ureteral stones: A retrospective study.
Medicine · 2024-08 · Min K, Kim BS, Ha YS 외 10
- Profiling of endogenous metabolites and changes in intestinal microbiota distribution after GEN-001 (Lactococcus lactis) administration.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024-03 · Kim MG, Kim S, Jeon JY 외 9
Show 17 more publications
- Prediction of lung cancer using novel biomarkers based on microbiome profiling of bronchoalveolar lavage fluid.
Scientific reports · 2024-01 · Kim G, Park C, Yoon YK 외 8
- Intracellular Adhesion Molecule-1 Improves Responsiveness to Immune Checkpoint Inhibitor by Activating CD8+ T Cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023-06 · Lee SH, Kim Y, Jeon BN 외 21
- Bifidobacterial carbohydrate/nucleoside metabolism enhances oxidative phosphorylation in white adipose tissue to protect against diet-induced obesity.
Microbiome · 2022-11 · Kim G, Yoon Y, Park JH 외 25
- Staphylococcus epidermidis WF2R11 Suppresses PM2.5-Mediated Activation of the Aryl Hydrocarbon Receptor in HaCaT Keratinocytes.
Probiotics and antimicrobial proteins · 2022-10 · Lee E, Ahn H, Park S 외 6
- Live Biotherapeutic Lactococcus lactis GEN3013 Enhances Antitumor Efficacy of Cancer Treatment via Modulation of Cancer Progression and Immune System.
Cancers · 2022-08 · Kim S, Kim Y, Lee S 외 4
- Potential Therapeutic Skin Microbiomes Suppressing Staphylococcus aureus-Derived Immune Responses and Upregulating Skin Barrier Function-Related Genes via the AhR Signaling Pathway.
International journal of molecular sciences · 2022-08 · Lee E, Min K, Ahn H 외 7
- Integrated metagenomics and metabolomics analysis illustrates the systemic impact of the gut microbiota on host metabolism after bariatric surgery.
Diabetes, obesity & metabolism · 2022-07 · Han Y, Kim G, Ahn E 외 8
- FBI-1 inhibits epithelial-to-mesenchymal transition, migration, and invasion in lung adenocarcinoma A549 cells by downregulating transforming growth factor-β1 signaling pathway.
Journal of cellular biochemistry · 2022-03 · Lim W, Jeon BN, Kim YJ 외 2
- Gut microbiome alterations in preclinical Alzheimer's disease.
PloS one · 2022-01 · Jung JH, Kim G, Byun MS 외 4
- Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice.
Nature microbiology · 2021-03 · Lee SH, Cho SY, Yoon Y 외 30
- Bifidobacterium Strain-Specific Enhances the Efficacy of Cancer Therapeutics in Tumor-Bearing Mice.
Cancers · 2021-02 · Yoon Y, Kim G, Jeon BN 외 2
- Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome.
Communications biology · 2021-02 · Kim G, Kim M, Kim M 외 15
- Practical prediction model of the clinical response to programmed death-ligand 1 inhibitors in advanced gastric cancer.
Experimental & molecular medicine · 2021-02 · Noh MG, Yoon Y, Kim G 외 6
- Lactobacillus fermentum promotes adipose tissue oxidative phosphorylation to protect against diet-induced obesity.
Experimental & molecular medicine · 2020-09 · Yoon Y, Kim G, Noh MG 외 4
- Sodium butyrate inhibits high cholesterol-induced neuronal amyloidogenesis by modulating NRF2 stabilization-mediated ROS levels: involvement of NOX2 and SOD1.
Cell death & disease · 2020-06 · Kim SY, Chae CW, Lee HJ 외 9
- Catechol inhibits epidermal growth factor-induced epithelial-to-mesenchymal transition and stem cell-like properties in hepatocellular carcinoma cells.
Scientific reports · 2020-05 · Lim WC, Kim H, Kim YJ 외 3
- Anaerosacchariphilus polymeriproducens gen. nov., sp. nov., an anaerobic bacterium isolated from a salt field.
International journal of systematic and evolutionary microbiology · 2019-07 · Kim W, Yang SH, Park MJ 외 3
Patents
KIPRIS · applicant-matchedRegistered · 2025-11 · Application 1020250174119
Published · 2025-04 · Application 1020250042404
Published · 2025-03 · Application 1020250035615
Withdrawn · 2024-11 · Application 1020240153281
Registered · 2024-10 · Application 1020240144445
Registered · 2024-10 · Application 1020240144429
Registered · 2024-09 · Application 1020240125903
Published · 2024-05 · Application 1020240063246
Published · 2024-03 · Application 1020240034133
Published · 2023-11 · Application 1020257020363
Show 32 more patents
Rejected · 2023-06 · Application 1020230073225
Registered · 2023-05 · Application 1020230064669
Published · 2023-04 · Application 1020230044305
Published · 2023-02 · Application 1020230020056
Registered · 2021-11 · Application 1020210160740
Registered · 2021-08 · Application 1020210103584
Withdrawn · 2021-06 · Application 1020210073076
Registered · 2021-05 · Application 1020210065517
Withdrawn · 2021-04 · Application 1020210046810
Registered · 2021-04 · Application 1020210044840
Registered · 2021-04 · Application 1020210043018
Withdrawn · 2021-03 · Application 1020210032882
- Subsidiary: Scioto Biosciences, Inc.METHODS FOR TREATING OR AMELIORATING AUTISM AND RELATED DISORDERS
US · Published · 2021-01 · Application 17792329
- Subsidiary: Scioto Biosciences, Inc.METHODS FOR TREATING OR AMELIORATING AUTISM AND RELATED DISORDERS
EP · Published · 2021-01 · Application 21741182.6
- Subsidiary: Scioto Biosciences, Inc.METHODS FOR TREATING OR AMELIORATING AUTISM AND RELATED DISORDERS
PCT · Published · 2021-01 · Application PCT/US2021/013280
Registered · 2020-12 · Application 1020200179067
Rejected · 2020-12 · Application 1020200168197
Registered · 2019-10 · Application 1020190130275
Registered · 2019-06 · Application 1020190069415
Expired · 2019-05 · Application 1020190063566
Expired · 2019-05 · Application 1020190057103
Registered · 2019-05 · Application 1020190053963
Registered · 2019-04 · Application 1020190039278
Expired · 2019-01 · Application 1020190004226
Registered · 2018-08 · Application 1020180098880
Registered · 2018-08 · Application 1020180098879
Rejected · 2018-05 · Application 1020180062041
Registered · 2018-04 · Application 1020180042912
Registered · 2018-03 · Application 1020180034612
Registered · 2017-10 · Application 1020170133007
Registered · 2017-09 · Application 1020170113645
- Subsidiary: List Biological Laboratories, Inc.Anthrax lethal factor substrates and methods of use thereof
US · Registered · 2016-07 · Application 15216556
AI reads
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How to connect (MCP)Companies in the same categoryBiotech & Drug Discovery
KOSDAQ-listed integrated security company behind the V3 antivirus and AhnLab TrusGuard and XDR solutions.
Drug delivery system company behind the long-acting injectable platform IVL-DrugFluidic and the LNP delivery platform IVL-GeneFluidic.
Organoid-based biotech founded 2018, KOSDAQ-listed 2025, developing the ATORM-C regenerative therapeutic and ODISEI evaluation solution.
EDGC, a Korea-US joint venture of Eone Medical Foundation and Diagnomics, offers the NIPT service NICE and liquid biopsy OncoCatch.
A diversified SK group company operating eco-friendly chemical materials alongside pharmaceutical products like Joins and vaccines through subsidiary SK Bioscience.
Genomics and drug developer behind the osteoarthritis drug Acelex and the AI-driven healthcare platform Invites Loop.
KOSDAQ-listed antibody biotech developing the next-generation immuno-oncology candidate Multi-AbKine on its fully human antibody library Ymax®-ABL.
A holding company overseeing 54 affiliates including its main biopharmaceutical subsidiary GC, with no direct product manufacturing of its own.
Founded in 2015 and listed on KOSPI in 2021, Prestige BioPharma develops antibody biosimilars and novel antibody drugs including Tuznue.
KOSDAQ-listed biotech company developing molecular diagnostics with proprietary C-Tag technology and the NeoPlex product line.
SillaJen, Inc., founded in 2006 and listed on KOSDAQ in 2016, develops the oncolytic virus immunotherapy Pexa-Vec.
A vaccine specialist developing in-house products such as SKYCellflu and SKYZoster while also serving as CDMO for AstraZeneca and Novavax.
Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
- Company basics
- Korea Exchange · DART
- Business content
- Compiled from disclosure filings
- Approvals & clinical trials
- Korean MFDS (data.go.kr) · US FDA openFDA — updated weekly
- Key disclosures
- KRX KIND via OpenDART exchange filings — updated daily
- Global clinical trials
- ClinicalTrials.gov (US NIH) — sponsor-matched, updated weekly
- Financials
- DART corporate disclosure filings — annual
- Publications
- PubMed (US National Library of Medicine) — affiliation-matched, updated daily
- Patents
- KIPRIS (Korea Institute of Patent Information) — applicant-matched, updated monthly
- AI reads
- Our server logs, IP-verified every 6 hours
- AI visibility
- Measured 2026-10-01
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