Epi Biotech Co., Ltd.
Founded 2015, KONEX-listed Epi Biotech develops a hair-loss pipeline spanning dermal papilla cell, antibody, and gene therapies.
As of 2026-10-10, Epi Biotech Co., Ltd. has 24 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
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Business overview
Source: DART corporate disclosureFounded in 2015 and listed on KONEX in 2023, Epi Biotech develops hair loss treatments. EPI-001, an autologous dermal papilla cell therapy, received IND approval and entered Phase 1/2a trials; the pipeline also includes EPI-002, EPI-005, EPI-007, and EPI-008. EPI-005 has completed antibody production against target CXCL12, while over 200,000 people in Korea are treated for hair loss yearly.
Clinical trials
data.go.kr1 MFDS clinical trial authorisations · 2023 (Phase 1/2a 1)
- Phase 1/2aEPI-0012023-12-20
1 trial site
R&D and key agreements
Source: DART corporate disclosureEPI-001 · 안드로겐 탈모증(남성형, 여성형) · 임상 1/2a상 · Autologous dermal papilla cell hair-loss therapy; received IND approval from Korea's MFDS and entered Phase 1, with proprietary dermal papilla cell isolation/culture technology and related patents.
EPI-002 · 안드로겐 탈모증(여성형) · 비임상/CMC 개발 · Topical hair-loss treatment; completed in vitro/in vivo efficacy testing and is developing CMC processes while preparing nonclinical toxicity and efficacy studies.
EPI-005 · 원형탈모 및 안드로겐 탈모증 · 전임상(항체 개발) · Alopecia areata antibody therapy; secured the CXCL12 target affecting the hair growth cycle and completed antibody production, with binding-affinity optimization underway and CMC development planned for Q4.
EPI-007 · 원형탈모 · 전임상 · Hair-loss gene therapy; efficacy demonstrated in animal studies and mechanism-of-action research completed, with nonclinical safety studies planned.
EPI-008 · 안드로겐 탈모증(남성형, 여성형) · 전임상(원료세포 개발) · Allogeneic dermal papilla cell hair-loss therapy; researching a hypoxic culture method to reduce expression of immunogenic proteins, and preparing candidate source cells for productization.
Key disclosures
KRX KIND via OpenDARTPublications
PubMed · affiliation-matched- Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment.
Journal of ethnopharmacology · 2027-01 · Kwon HY, Lee H, Choi JS 외 10
- Corrigendum to "Fermented Morinda citrifolia extract stimulates hair growth by promoting dermal papilla cell proliferation and modulating the follicular microenvironment" [J. Ethnopharmacol. 372, (2027), 122238].
Journal of ethnopharmacology · 2026-09 · Kwon HY, Lee H, Choi JS 외 10
- Venlafaxine reverses chemotherapy-induced alopecia through epithelial and dermal reprogramming at single-cell resolution.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2026-07 · Zheng M, Cho J, Song L 외 6
- Off‑the‑shelf, engineered non-living stem cell strategy for advancing cellular therapies.
Nature biomedical engineering · 2026-06 · Nguyen TT, Nguyen NN, Nguyen L 외 6
- DKK3-CKAP4 signaling drives fibroimmune remodeling and hair follicle miniaturization in androgenetic alopecia.
Theranostics · 2026-01 · An S, Kim H, Zheng M 외 5
- Insights into the context-dependent immunological roles of the CXCL12-CXCR4 axis in alopecia.
Frontiers in immunology · 2026-01 · Sung JH, Zheng M, Park IG 외 3
- Special Issue "Molecular Insights into Hair Regeneration".
International journal of molecular sciences · 2026-01 · Sung JH
- CXCL12 Drives Reversible Fibroimmune Remodeling in Androgenetic Alopecia Revealed by Single-Cell RNA Sequencing.
International journal of molecular sciences · 2025-07 · An S, Zheng M, Park IG 외 4
- Recent Advances in Drug Development for Hair Loss.
International journal of molecular sciences · 2025-04 · Kim J, Song SY, Sung JH
- The Involvement of RIPK1 in Alopecia Areata.
International journal of molecular sciences · 2025-02 · Kim H, Zheng M, An S 외 4
Show 14 more publications
- Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup.
International journal of molecular sciences · 2024-12 · Zheng M, An S, Park IG 외 4
- Differential expression of androgen receptor and 5-α reductase isoforms in skin cells.
Archives of dermatological research · 2024-12 · An S, Zheng M, Park IG 외 2
- Delivery Strategies of siRNA Therapeutics for Hair Loss Therapy.
International journal of molecular sciences · 2024-07 · Jin SE, Sung JH
- Involvement of DKK1 secreted from adipose-derived stem cells in alopecia areata.
Cell proliferation · 2024-03 · Choi N, Hwang J, Kim DY 외 3
- CXCL12 Neutralizing Antibody Promotes Hair Growth in Androgenic Alopecia and Alopecia Areata.
International journal of molecular sciences · 2024-01 · Zheng M, Kim MH, Park SG 외 3
- Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing.
Frontiers in immunology · 2024-01 · An S, Zheng M, Park IG 외 3
- Recent approaches of antibody therapeutics in androgenetic alopecia.
Frontiers in pharmacology · 2024-01 · Jin SE, Kim J, Sung JH
- Hair growth promoting effects of human dermal papilla cells in pig.
Experimental dermatology · 2023-07 · Hwang J, Zheng M, Le TNH 외 2
- The effects of GPR40 agonists on hair growth are mediated by ANGPTL4.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023-05 · Kim DY, Sung JH
- Hypoxia enhances the hair growth-promoting effects of embryonic stem cell-derived mesenchymal stem cells via NADPH oxidase 4.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023-03 · Jeon SH, Kim H, Sung JH
- Effective and economical cell therapy for hair regeneration.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023-01 · Sung JH
- Hair Growth Regulation by Fibroblast Growth Factor 12 (FGF12).
International journal of molecular sciences · 2022-08 · Woo J, Suh W, Sung JH
- CXCL12 inhibits hair growth through CXCR4.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2022-06 · Zheng M, Oh SH, Choi N 외 3
- TGF-β2 and collagen play pivotal roles in the spheroid formation and anti-aging of human dermal papilla cells.
Aging · 2021-08 · Kim H, Choi N, Kim DY 외 3
Patents
KIPRIS · applicant-matchedRegistered · 2025-11 · Application 1020250164772
Registered · 2025-09 · Application 1020250126535
US · Published · 2024-06 · Application 18754060
Published · 2023-12 · Application 1020230177277
PCT · Published · 2023-09 · Application PCT/KR2023/013272
Withdrawn · 2023-02 · Application 1020230018279
Rejected · 2023-01 · Application 1020230002358
EP · Published · 2022-12 · Application 22916635.0
PCT · Published · 2022-12 · Application PCT/KR2022/021227
Registered · 2022-12 · Application 1020220183286
Show 33 more patents
PCT · Published · 2022-12 · Application PCT/KR2022/020123
US · Published · 2022-05 · Application 18561931
EP · Published · 2022-05 · Application 22804940.9
PCT · Published · 2022-05 · Application PCT/KR2022/006996
Published · 2022-05 · Application 1020220059791
Withdrawn · 2021-12 · Application 1020210186527
PCT · Published · 2021-11 · Application PCT/KR2021/017480
Registered · 2021-10 · Application 1020210135996
PCT · Published · 2021-10 · Application PCT/KR2021/013839
Registered · 2021-01 · Application 1020210011810
US · Published · 2020-10 · Application 17766675
EP · Published · 2020-10 · Application 20876107.2
Withdrawn · 2020-10 · Application 1020200131466
Withdrawn · 2020-09 · Application 1020200126866
Rejected · 2020-09 · Application 1020200115228
Registered · 2020-08 · Application 1020200101144
US · Published · 2020-08 · Application 17633317
Withdrawn · 2020-07 · Application 1020200085690
Registered · 2020-06 · Application 1020200070274
Expired · 2020-04 · Application 1020200052217
Withdrawn · 2020-04 · Application 1020200052593
Withdrawn · 2020-02 · Application 1020200020639
Rejected · 2020-02 · Application 1020200013961
Rejected · 2019-12 · Application 1020190176082
Rejected · 2019-12 · Application 1020190174523
Rejected · 2019-12 · Application 1020190166235
Rejected · 2019-12 · Application 1020190166267
Withdrawn · 2019-04 · Application 1020190050226
Registered · 2019-02 · Application 1020190022918
Rejected · 2018-08 · Application 1020180102202
Registered · 2016-09 · Application 1020160123803
Expired · 2016-07 · Application 1020160091563
Expired · 2016-05 · Application 1020160060403
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Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
- Company basics
- Korea Exchange · DART
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- Measured 2026-10-01
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