Raphas Co., Ltd.
KOSDAQ-listed transdermal drug delivery (TDDS) company developing dissolving microneedle patches based on its proprietary DEN technology.
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Business overview
Source: DART corporate disclosureFounded in 2006 and listed on KOSDAQ in 2019, Raphas is a company specializing in dissolving microneedle patches based on transdermal drug delivery (TDDS) technology. It uses its proprietary DEN (Droplet Extension) technology to manufacture beauty patches and over-the-counter drug patches, while developing prescription drug patches, vaccine patches, and a blood-glucose diagnostic device. Its DEN technology achieves a yield above 90% with monthly production of millions of microneedle patches; it has in-licensed the Mpg tuberculosis vaccine technology from Seoul National University (KRW 300 million upfront, up to KRW 1.2 billion in milestones), co-develops hepatitis B and polio vaccine patches with the Serum Institute, and jointly develops donepezil and other drug patches with Boryung Pharmaceutical (KRW 200 million upfront, up to KRW 800 million in milestones).
Products & technology
- Beauty microneedle patchHigh-functionality beauty-care microneedle patch
- OTC drug microneedle patchOTC transdermal drug delivery patch
- Drug absorption enhancer deviceMedical device to enhance drug absorption
- Blood-glucose diagnostic deviceDiagnostic device for blood glucose measurement
Regulatory approvals
data.go.kr3 Korean MFDS device approvals · 2016–2026
- MFDSAcupuncture needle, reusable2026-04-13Product approval · Class 1제신 26-435 호
- MFDSAcupuncture and moxibustion apparatus2026-01-12Product approval · Class 3제허 26-37 호
- MFDSDepressors for medical use2016-05-12Product approval · Class 3제허 16-349 호
Clinical trials
data.go.kr3 MFDS clinical trial authorisations · 2018–2021 (Phase 1 3)
- Phase 1DF190012021-10-18
1 trial site
- Phase 1Rap180012020-03-18
2 trial sites
- Phase 1Rap180012018-10-01
1 trial site
R&D and key agreements
Source: DART corporate disclosure전문의약품 패치 · 연구개발 · R&D on prescription drug microneedle patches
백신 패치(B형간염, 소아마비) · B형간염, 소아마비 · 동물실험 효능 확인 · Joint research with Serum Institute; HBV efficacy confirmed via animal studies in 2017-2018, IPV joint research ongoing since 2018
Mpg 결핵백신 · 결핵 · 제제연구 및 전임상 · In-licensed strain from Seoul National University; commercial culture and animal efficacy evaluation underway
3D 마이크로회절리소그래피 기반 마이크로니들 제조방법 · 제조공정 연구 · Co-owns 50% of patent with Kansas State University; process R&D underway under a Ministry of Trade, Industry and Energy government project
Companies approved for the same productsMedical Devices
Ranked by how many MFDS product categories overlap. Not a ranking — a pointer to where to look.
DIO Corporation, established in 1988 and listed on KOSDAQ in 2000, manufactures and sells dental implants.
KOSDAQ-listed medical device maker producing disposable acupuncture needles, cupping cups, and hyaluronic acid dermal fillers.
Manufactures spinal implants and metal 3D-printed patient-specific implants, exporting to over 25 countries.
Founded 2009, listed on KOSDAQ in 2019, JETEMA develops hyaluronic acid fillers, botulinum toxin biopharmaceuticals, and lifting threads.
Founded in 2000 and KOSDAQ-listed in 2013, i-SENS makes blood glucose monitors and point-of-care testing devices.
Founded in 2010 and KOSDAQ-listed in 2018, Sejong Medical manufactures laparoscopic surgical instruments.
Founded in 1987 and listed on KOSDAQ in 2000, NanoenTek develops Lab-On-a-Chip in-vitro diagnostic devices and life science instruments.
Founded in 2015 and listed on KOSDAQ in 2022, Noul develops the on-device AI diagnostic platform miLab™ for blood and cancer testing.
KOSDAQ-listed manufacturer of diagnostic X-ray imaging systems and core components such as generators and tubes.
KOSDAQ-listed molecular genetic diagnostics company providing NGS-based non-invasive prenatal testing (NIPT) under the MomGuard brand.
Founded in 2000 and KOSDAQ-listed in 2013, Corentec makes artificial joints; hip and knee implants exceed 85% of revenue.
Established in 2012 and listed on KOSDAQ in 2018, Osteonic manufactures implants for the CMF, Trauma, Sports Medicine, and Spine categories.
Sources and updates
- Company basics
- Korea Exchange · DART
- Business content
- Compiled from disclosure filings
- AI visibility
- Measured 2026-08-13
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