Raphas Co., Ltd.
KOSDAQ-listed transdermal drug delivery (TDDS) company developing dissolving microneedle patches based on its proprietary DEN technology.
As of 2026-10-10, Raphas Co., Ltd. has 3 Korean MFDS device approvals, 30 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
Price
Change
Market cap
Business overview
Source: DART corporate disclosureFounded in 2006 and listed on KOSDAQ in 2019, Raphas is a company specializing in dissolving microneedle patches based on transdermal drug delivery (TDDS) technology. It uses its proprietary DEN (Droplet Extension) technology to manufacture beauty patches and over-the-counter drug patches, while developing prescription drug patches, vaccine patches, and a blood-glucose diagnostic device. Its DEN technology achieves a yield above 90% with monthly production of millions of microneedle patches; it has in-licensed the Mpg tuberculosis vaccine technology from Seoul National University (KRW 300 million upfront, up to KRW 1.2 billion in milestones), co-develops hepatitis B and polio vaccine patches with the Serum Institute, and jointly develops donepezil and other drug patches with Boryung Pharmaceutical (KRW 200 million upfront, up to KRW 800 million in milestones).
Products & technology
- Beauty microneedle patchHigh-functionality beauty-care microneedle patch
- OTC drug microneedle patchOTC transdermal drug delivery patch
- Drug absorption enhancer deviceMedical device to enhance drug absorption
- Blood-glucose diagnostic deviceDiagnostic device for blood glucose measurement
Regulatory approvals
data.go.kr3 Korean MFDS device approvals · 2016–2026
- MFDSAcupuncture needle, reusable2026-04-13Product approval · Class 1제신 26-435 호
- MFDSAcupuncture and moxibustion apparatus2026-01-12Product approval · Class 3제허 26-37 호
- MFDSDepressors for medical use2016-05-12Product approval · Class 3제허 16-349 호
Clinical trials
data.go.kr3 MFDS clinical trial authorisations · 2018–2021 (Phase 1 3)
- Phase 1DF190012021-10-18
1 trial site
- Phase 1Rap180012020-03-18
2 trial sites
- Phase 1Rap180012018-10-01
1 trial site
Global clinical trials
ClinicalTrials.gov · sponsor-matchedPhase 1 · Unknown · 2022-01 · NCT05525650
R&D and key agreements
Source: DART corporate disclosure전문의약품 패치 · 연구개발 · R&D on prescription drug microneedle patches
백신 패치(B형간염, 소아마비) · B형간염, 소아마비 · 동물실험 효능 확인 · Joint research with Serum Institute; HBV efficacy confirmed via animal studies in 2017-2018, IPV joint research ongoing since 2018
Mpg 결핵백신 · 결핵 · 제제연구 및 전임상 · In-licensed strain from Seoul National University; commercial culture and animal efficacy evaluation underway
3D 마이크로회절리소그래피 기반 마이크로니들 제조방법 · 제조공정 연구 · Co-owns 50% of patent with Kansas State University; process R&D underway under a Ministry of Trade, Industry and Energy government project
Key disclosures
KRX KIND via OpenDARTShow 2 more events
Publications
PubMed · affiliation-matched- Sensitive Skin Improvement Through Bioinformatics-Identified Cosmetic Ingredients That Regulate Transcriptome-Derived Biomarkers.
Biomolecules · 2026-06 · Kim SH, Kim JH, Shin JM 외 9
- Inactivated mycobacterium paragordonae delivered via microneedle patches as a novel tuberculosis booster vaccine.
Human vaccines & immunotherapeutics · 2025-12 · Lee M, Jeong D, Yoon K 외 6
- Acupoint stimulation by microneedle alleviates motor dysfunction through modulating striatal dopamine and choline levels and reducing neuroinflammation in the Parkinson's disease mouse model.
Journal of traditional and complementary medicine · 2025-10 · Kim JH, Ju IG, Choi Y 외 9
- Additional Use of Hyaluronic Acid-Based Dissolving Microneedle Patches to Treat Psoriatic Plaques: A Randomized Controlled Trial.
Annals of dermatology · 2025-04 · Ju HJ, Kim JY, Jeong DH 외 4
- White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin.
Journal of controlled release : official journal of the Controlled Release Society · 2025-02 · Dul M, Alali M, Ameri M 외 25
- The Long-Term Immunity of a Microneedle Array Patch of a SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice.
Vaccines · 2025-01 · Kim E, Khan MS, Shin J 외 9
- Long-term Immunity of a Microneedle Array Patch of SARS-CoV-2 S1 Protein Subunit Vaccine Irradiated by Gamma Rays in Mice.
bioRxiv : the preprint server for biology · 2024-10 · Kim E, Khan MS, Shin J 외 9
- Development of a biomarker-based platform for comprehensive skin characterization using minimally invasive skin sampling and quantitative real-time PCR.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024-08 · Kim SH, Kim JH, Choi YM 외 9
- Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities.
Annals of dermatology · 2024-08 · Shin JY, Han D, Yoon KY 외 2
- Fourth dose of microneedle array patch of SARS-CoV-2 S1 protein subunit vaccine elicits robust long-lasting humoral responses in mice.
International immunopharmacology · 2024-03 · Kim E, Shin J, Ferrari A 외 9
Show 20 more publications
- Microneedles: A novel clinical technology for evaluating skin characteristics.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024-03 · Kim SH, Kim JH, Choi YM 외 6
- Stimulation of microneedles alleviates pathology of Parkinson's disease in mice by regulating the CD4+/CD8+ cells from the periphery to the brain.
Frontiers in immunology · 2024-01 · Kim JH, Choi Y, Kim JS 외 8
- Assessing the risk of a clinically significant infection from a Microneedle Array Patch (MAP) product.
Journal of controlled release : official journal of the Controlled Release Society · 2023-09 · Dul M, Alali M, Ameri M 외 27
- Development of a novel microneedle platform for biomarker assessment of atopic dermatitis patients.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023-07 · Lee KH, Kim JD, Jeong DH 외 3
- A comparative study on a biodegradable hyaluronic acid microneedle patch with a needleless patch for dry skin in atopic dermatitis: a single-blinded, split-body, randomized controlled trial.
Archives of dermatological research · 2023-04 · Song JH, An EJ, Sung CY 외 3
- Protection against tuberculosis achieved by dissolving microneedle patches loaded with live Mycobacterium paragordonae in a BCG prime-boost strategy.
Frontiers in immunology · 2023-01 · Lee MH, Seo H, Lee MS 외 8
- Dissolvable Microneedle Patch Increases the Therapeutic Effect of Jawoongo on DNCB-Induced Atopic Dermatitis in Mice.
Complementary medicine research · 2023-01 · Jang HM, Kim H, Park SY 외 4
- Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model.
Drug delivery · 2022-12 · Nguyen CD, Yoo J, An EJ 외 5
- Local Disordering in the Amorphous Network of a Solution-Processed Indium Tin Oxide Thin Film.
ACS applied materials & interfaces · 2022-06 · Seo H, Kim B, Lee KH 외 2
- Minimally invasive skin sampling and transcriptome analysis using microneedles for skin type biomarker research.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022-03 · Kim SH, Kim JH, Lee SJ 외 3
- Clinical efficacy of dissolvable microneedles armed with anti-melanogenic compounds to counter hyperpigmentation.
Journal of cosmetic dermatology · 2021-02 · Avcil M, Akman G, Klokkers J 외 2
- Comparison of Allergenic Properties among Commercially Available House Dust Mite Allergen Extracts in Korea.
Yonsei medical journal · 2021-01 · Kim JT, Kim H, Kim SH 외 10
- Efficacy of transdermal immunotherapy with biodegradable microneedle patches in a murine asthma model.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2020-09 · Park KH, Oh EY, Han H 외 11
- Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.
Journal of cosmetic dermatology · 2020-02 · Avcil M, Akman G, Klokkers J 외 2
- Enhanced anti-tumor immunotherapy by dissolving microneedle patch loaded ovalbumin.
PloS one · 2019-01 · Lee SJ, Lee HS, Hwang YH 외 8
- Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.
ACS nano · 2018-10 · Kim NW, Kim SY, Lee JE 외 13
- A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery.
Biomaterials science · 2018-09 · Kim HK, Lee SH, Lee BY 외 7
- Ultrathin Metal Crystals: Growth on Supported Graphene Surfaces and Applications.
Small (Weinheim an der Bergstrasse, Germany) · 2018-09 · Chae SS, Jang S, Lee W 외 7
- The use of biodegradable microneedle patches to increase penetration of topical steroid for prurigo nodularis.
European journal of dermatology : EJD · 2018-02 · Shin JU, Kim JD, Kim HK 외 9
- Successful transdermal allergen delivery and allergen-specific immunotherapy using biodegradable microneedle patches.
Biomaterials · 2018-01 · Kim JH, Shin JU, Kim SH 외 12
Patents
KIPRIS · applicant-matchedPCT · Published · 2025-11 · Application PCT/KR2025/018017
Published · 2025-10 · Application 1020250160077
PCT · Published · 2025-10 · Application PCT/KR2025/015630
PCT · Published · 2025-10 · Application PCT/KR2025/015614
PCT · Published · 2025-06 · Application PCT/KR2025/008859
Published · 2025-06 · Application 1020250084052
PCT · Published · 2025-06 · Application PCT/KR2025/008065
Published · 2024-11 · Application 1020240164280
PCT · Published · 2024-11 · Application PCT/KR2024/017809
Published · 2024-10 · Application 1020240135397
Show 129 more patents
Published · 2024-10 · Application 1020240135390
TW · Published · 2024-10 · Application 113138008
PCT · Published · 2024-10 · Application PCT/JP2024/035603
Published · 2024-10 · Application 1020267014049
Published · 2024-07 · Application 1020240086303
PCT · Published · 2024-04 · Application PCT/KR2024/005321
Published · 2024-04 · Application 1020240052887
Published · 2023-11 · Application 1020230158990
CN · Published · 2023-10 · Application 202380087982.X
US · Published · 2023-10 · Application 19140570
PCT · Published · 2023-10 · Application PCT/KR2023/015239
Withdrawn · 2023-03 · Application 1020230042381
Rejected · 2023-03 · Application 1020230042374
US · Published · 2023-03 · Application 18850065
PCT · Published · 2023-03 · Application PCT/KR2023/004055
Registered · 2022-12 · Application 1020220183687
CN · Published · 2022-12 · Application 202280102675.X
US · Published · 2022-12 · Application 19138690
PCT · Published · 2022-12 · Application PCT/KR2022/020734
Registered · 2022-11 · Application 1020220162324
Registered · 2022-11 · Application 1020220154299
US · Published · 2022-07 · Application 17862315
Registered · 2022-05 · Application 1020220059367
PCT · Published · 2022-04 · Application PCT/KR2022/005574
US · Published · 2022-04 · Application 18287455
PCT · Published · 2022-04 · Application PCT/KR2022/005179
PCT · Published · 2022-04 · Application PCT/KR2022/004915
Rejected · 2021-12 · Application 1020210194676
US · Published · 2021-12 · Application 17552954
Registered · 2021-12 · Application 1020210178814
Registered · 2021-08 · Application 1020210101776
Registered · 2021-07 · Application 1020210095731
US · Published · 2021-07 · Application 17380258
Rejected · 2021-07 · Application 1020210089654
Registered · 2021-06 · Application 1020210083879
US · Registered · 2021-06 · Application 17343061
Registered · 2021-04 · Application 1020210050308
Registered · 2021-04 · Application 1020210050307
Registered · 2021-04 · Application 1020210044888
CN · Published · 2021-01 · Application 202180022017.5
EP · Published · 2021-01 · Application 21741390.5
PCT · Published · 2021-01 · Application PCT/US2021/013629
Registered · 2021-01 · Application 1020227028256
Registered · 2020-11 · Application 1020200153821
Registered · 2020-11 · Application 1020200153820
Withdrawn · 2020-09 · Application 1020200117645
Registered · 2020-07 · Application 1020200090199
CN · Published · 2020-06 · Application 202080099482.4
US · Published · 2020-06 · Application 17995559
EP · Registered · 2020-06 · Application 20930116.7
PCT · Published · 2020-06 · Application PCT/KR2020/007612
EP · Registered · 2020-06 · Application 20826621.3
PCT · Published · 2020-06 · Application PCT/KR2020/007408
Registered · 2020-04 · Application 1020200041957
Withdrawn · 2019-10 · Application 1020190127922
Withdrawn · 2019-09 · Application 1020190120940
Registered · 2019-06 · Application 1020190074059
CN · Published · 2019-06 · Application 201980081543.1
EP · Published · 2019-06 · Application 19894991.9
PCT · Published · 2019-06 · Application PCT/KR2019/007466
CN · Published · 2019-06 · Application 201980089834.5
EP · Published · 2019-06 · Application 19912866.1
PCT · Published · 2019-06 · Application PCT/KR2019/007413
Registered · 2019-01 · Application 1020190011763
Registered · 2019-01 · Application 1020190001812
Registered · 2018-12 · Application 1020180159987
Registered · 2018-06 · Application 1020180073199
CN · Published · 2018-05 · Application 201880033119.5
US · Registered · 2018-05 · Application 16614527
EP · Registered · 2018-05 · Application 18801678.6
PCT · Published · 2018-05 · Application PCT/KR2018/005614
US · Registered · 2018-03 · Application 15927389
PCT · Published · 2018-02 · Application PCT/KR2018/001888
Registered · 2018-01 · Application 1020180003748
Registered · 2017-09 · Application 1020170122216
Rejected · 2017-09 · Application 1020170114044
CN · Published · 2017-07 · Application 201780049577.3
US · Published · 2017-07 · Application 16324725
EP · Registered · 2017-07 · Application 17839657.8
PCT · Published · 2017-07 · Application PCT/KR2017/007030
JP · Registered · 2017-07 · Application 31507740
PCT · Published · 2017-06 · Application PCT/KR2017/006349
Registered · 2017-05 · Application 1020170062465
EP · Registered · 2017-04 · Application 17799571.9
PCT · Published · 2017-04 · Application PCT/KR2017/004059
PCT · Published · 2017-04 · Application PCT/KR2017/004058
Registered · 2016-10 · Application 1020160139215
Registered · 2016-09 · Application 1020160118309
PCT · Published · 2016-08 · Application PCT/KR2016/009744
PCT · Published · 2016-08 · Application PCT/KR2016/009739
PCT · Published · 2016-08 · Application PCT/KR2016/009738
US · Registered · 2016-08 · Application 15248339
US · Registered · 2016-08 · Application 15248354
EP · Registered · 2016-08 · Application 16185915.2
EP · Registered · 2016-08 · Application 16185914.5
CN · Published · 2016-08 · Application 201610665334.X
CN · Published · 2016-08 · Application 201610663744.0
Registered · 2016-08 · Application 1020160103053
Withdrawn · 2016-06 · Application 1020160081209
Withdrawn · 2016-06 · Application 1020160081210
Registered · 2016-05 · Application 1020160061909
Registered · 2016-05 · Application 1020160061903
Registered · 2015-12 · Application 1020150189855
Registered · 2015-12 · Application 1020150189063
Registered · 2015-12 · Application 1020150174066
Rejected · 2015-10 · Application 1020150141862
Registered · 2015-10 · Application 1020150141865
Withdrawn · 2014-07 · Application 1020140086648
US · Published · 2014-01 · Application 14163338
Registered · 2012-11 · Application 1020120137978
CN · Published · 2012-07 · Application 201280046973
EP · Registered · 2012-07 · Application 12818195.5
PCT · Published · 2012-07 · Application PCT/KR2012/005777
JP · Published · 2012-07 · Application 26522739
Registered · 2012-03 · Application 1020120029315
CN · Published · 2011-12 · Application 201610286681.1
EP · Registered · 2011-12 · Application 11847959.1
JP · Registered · 2011-12 · Application 25544399
Withdrawn · 2011-10 · Application 1020110102506
Registered · 2011-07 · Application 1020110074250
Registered · 2011-02 · Application 1020110010172
Registered · 2011-01 · Application 1020110005927
Registered · 2010-12 · Application 1020100130169
Registered · 2010-04 · Application 1020100030127
Expired · 2010-02 · Application 1020100014959
Registered · 2009-10 · Application 1020090094018
Registered · 2009-06 · Application 1020090052755
Rejected · 2008-10 · Application 1020080096699
Registered · 2008-06 · Application 1020080057469
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How to connect (MCP)Companies approved for the same productsMedical Devices
Ranked by how many MFDS product categories overlap. Not a ranking — a pointer to where to look.
DIO Corporation, established in 1988 and listed on KOSDAQ in 2000, manufactures and sells dental implants.
KOSDAQ-listed medical device maker producing disposable acupuncture needles, cupping cups, and hyaluronic acid dermal fillers.
Manufactures spinal implants and metal 3D-printed patient-specific implants, exporting to over 25 countries.
Interojo, founded 2000 and KOSDAQ-listed 2010, manufactures contact lenses under its Clalen brand domestically and via OEM/ODM overseas.
MITECH CO.,LTD., founded in 1991 and listed on KOSDAQ in 2018, makes non-vascular stents and distributes Fujifilm endoscopy equipment.
Founded 2009, listed on KOSDAQ in 2019, JETEMA develops hyaluronic acid fillers, botulinum toxin biopharmaceuticals, and lifting threads.
Founded in 2000 and KOSDAQ-listed in 2013, Corentec makes artificial joints; hip and knee implants exceed 85% of revenue.
Founded in 1987 and listed on KOSDAQ in 2000, NanoenTek develops Lab-On-a-Chip in-vitro diagnostic devices and life science instruments.
Founded in 2010 and KOSDAQ-listed in 2018, Sejong Medical manufactures laparoscopic surgical instruments.
Founded in 2012 and listed on KOSDAQ in 2026, REMEDI develops portable X-ray imaging devices based on its low-dose, miniaturized X-ray technology.
KOSDAQ-listed medical device company developing the LOTUS and HELIOS laser aesthetic devices and the PALLAS vitiligo treatment device.
Develops quantitative fluorescence biomarker technology for oral disease diagnostic devices.
Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
- Company basics
- Korea Exchange · DART
- Business content
- Compiled from disclosure filings
- Approvals & clinical trials
- Korean MFDS (data.go.kr) · US FDA openFDA — updated weekly
- Key disclosures
- KRX KIND via OpenDART exchange filings — updated daily
- Global clinical trials
- ClinicalTrials.gov (US NIH) — sponsor-matched, updated weekly
- Financials
- DART corporate disclosure filings — annual
- Publications
- PubMed (US National Library of Medicine) — affiliation-matched, updated daily
- Patents
- KIPRIS (Korea Institute of Patent Information) — applicant-matched, updated monthly
- AI reads
- Our server logs, IP-verified every 6 hours
- AI visibility
- Measured 2026-10-01
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