HEM Pharma Inc.
KOSDAQ-listed microbiome healthcare company using the PMAS gut-microbiome simulation platform and the PeachBiome028 probiotic strain.
As of 2026-10-10, HEM Pharma Inc. has 30 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
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Business overview
Source: DART corporate disclosureFounded in 2016 and listed on KOSDAQ in 2024, HEM Pharma is a microbiome-focused healthcare company. Using its PMAS gut-microbiome simulation technology, it operates personalized healthcare and LBP (live biotherapeutic product) discovery platform businesses, and holds the peach-derived probiotic strain PeachBiome028 (formally Lactiplantibacillus plantarum PeachBiome028, deposit no. KCCM13580P), combined with PDRN and EGF through its Multi Smart Formula formulation technology. PeachBiome028 has been verified to increase pro-collagen by 65%, improve skin regeneration about threefold, and inhibit harmful bacteria such as C. acnes by over 99.99%.
Products & technology
- PeachBiome028™peach-derived probiotic strain (skin regeneration, antibacterial)
- Multi Smart Formula™formulation technology combining PeachBiome028 with PDRN, EGF, collagen, and other ingredients
Global clinical trials
ClinicalTrials.gov · sponsor-matchedPhase 2 · Unknown · 2024-01 · NCT05527301
R&D and key agreements
Source: DART corporate disclosurePMAS(Personalized Pharmaceutical Meta-Analytical Screening) · LBP 후보물질·일반의약품·건강기능식품·파이토케미컬과 개인 마이크로바이옴 상호작용 연구 · 플랫폼 운영중 · Proprietary culture technology simulating fecal microbiome activity to study interactions with LBP candidates, drugs, supplements, and phytochemicals
Key disclosures
KRX KIND via OpenDARTPublications
PubMed · affiliation-matched- Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway.
Experimental & molecular medicine · 2026-09 · Kim NE, Cho B, Kim Y 외 21
- Fecal gas time curve analysis for health monitoring.
Journal of breath research · 2026-07 · Park JY, Park SH, Lee JH 외 1
- Effects of health-functional products on gut microbiota-derived short-chain fatty acids production: an ex vivo and pilot human study.
Food science and biotechnology · 2026-07 · Suh DH, Lee HJ, Ji Y 외 6
- Effects of Probiotic-Phytonutrient Blends on Defecation, Intestinal Barrier Function, and Gut Microbiota: A Randomized, Placebo-Controlled Trial.
Nutrients · 2026-06 · Hwang AY, Lee S, Yoon J 외 13
- Phytonutrient-Enriched Prebiotic Mixture Primes the Gut Environment to Enhance Probiotic Efficacy: Ex Vivo Screening and a Human Clinical Trial.
Biology · 2026-06 · Lee HJ, Suh DH, Lee S 외 7
- Emphysema severity-associated gut microbiota modulates smoke-induced emphysema: evidence from fecal microbiota transplantation.
Respiratory research · 2026-06 · Kim NH, Lee JH, Oh J 외 14
- Restoration of the Mucosal Barrier by Lactobacillus gasseri HDS0266 and Enterococcus faecium HDS0288 in Dextran Sodium Sulfate and Clostridioides difficile-Induced Colitis Mice.
Probiotics and antimicrobial proteins · 2026-04 · Kim E, Kim B, Kim H 외 9
- Limosilactobacillus fermentum ANC4 (KCTC 15072BP) Mitigates Dexamethasone-Induced Muscle Atrophy and Improves Overall Skeletal Muscle Function.
Journal of microbiology and biotechnology · 2026-04 · Hong SM, Park J, Kim SH 외 6
- A colon mimetic screening approach reveals Lactobacillus fermentum as a microbiome-based therapy for COPD.
NPJ biofilms and microbiomes · 2026-04 · Kim NH, Oh J, Lee JH 외 12
- Systems-level restoration of vaginal and gut microbiota by Lactobacillus helveticus 20838 alleviates Gardnerella vaginalis-induced dysbiosis.
The ISME journal · 2026-01 · Kim J, Kim WI, Lee K 외 7
Show 20 more publications
- Gut Microbiome and Metabolome Dynamics as Predictors of Clinical Outcomes in Hematopoietic Stem Cell Transplantation.
MedComm · 2025-09 · Kim J, Kim Y, Lee YJ 외 6
- Identifying robust biomarkers for the diagnosis and subtype distinction of inflammatory bowel disease through comprehensive serum metabolomic profiling.
Scientific reports · 2025-02 · Kim JE, Suh DH, Park YJ 외 8
- A microbiota-derived metabolite, 3-phenyllactic acid, prolongs healthspan by enhancing mitochondrial function and stress resilience via SKN-1/ATFS-1 in C. elegans.
Nature communications · 2024-12 · Kim J, Jo Y, Lim G 외 7
- Associations Between Skin Microbiome and Metabolome in the Pathogenesis of Atopic Dermatitis Patients With Scalp Involvement.
Allergy, asthma & immunology research · 2024-11 · Kim S, Suh DH, Lee S 외 3
- Collagen Type VII (COL7A1) as a Longevity Mediator in Caenorhabditis elegans: Anti-Aging Effects on Healthspan Extension and Skin Collagen Synthesis.
Biomolecules & therapeutics · 2024-11 · Kim J, Kim H, Seo WY 외 2
- Author Correction: Multifunctional effects of Lactobacillus sakei HEM 224 on the gastrointestinal tract and airway inflammation.
Scientific reports · 2024-07 · Kim HS, Oh H, Kim B 외 4
- Comprehensive Amelioration of Metabolic Dysfunction through Administration of Lactiplantibacillus plantarum APsulloc 331261 (GTB1™) in High-Fat-Diet-Fed Mice.
Foods (Basel, Switzerland) · 2024-07 · Kim B, Lee Y, Lee C 외 3
- Investigating Distinct Skin Microbial Communities and Skin Metabolome Profiles in Atopic Dermatitis.
International journal of molecular sciences · 2024-05 · Kim S, Cho M, Jung ES 외 2
- The impact of a modified microbiota-accessible carbohydrate diet on gut microbiome and clinical symptoms in colorectal cancer patients following surgical resection.
Frontiers in microbiology · 2024-01 · Kim B, Lee J, Jung ES 외 6
- Evaluation of the cervical liquid-based cytology sample as a microbiome resource for dual diagnosis.
PloS one · 2024-01 · Lim C, Seo YJ, Lee JY 외 5
- The animal protein hydrolysate attenuates sarcopenia via the muscle-gut axis in aged mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023-11 · Lee JY, Shin SK, Bae HR 외 3
- Multifunctional effects of Lactobacillus sakei HEM 224 on the gastrointestinal tract and airway inflammation.
Scientific reports · 2023-10 · Kim HS, Oh H, Kim B 외 4
- Bacillus Strains Isolated from Korean Fermented Food Products with Antimicrobial Activity Against Staphylococci, an Alternative for Control of Antibiotic-Resistant Pathogens.
Foodborne pathogens and disease · 2023-07 · Ye J, Fugaban JII, Dioso CM 외 5
- Lactobacillus johnsonii BFE6154 Ameliorates Diet-Induced Hypercholesterolemia.
Probiotics and antimicrobial proteins · 2023-06 · Yoon H, Lee Y, Park H 외 3
- Genomic, metabolomic, and functional characterisation of beneficial properties of Pediococcus pentosaceus ST58, isolated from human oral cavity.
Beneficial microbes · 2023-03 · Favaro L, Campanaro S, Fugaban JII 외 7
- Lactiplantibacillusplantarum APsulloc331261 (GTB1™) promotes butyrate production to suppress mucin hypersecretion in a murine allergic airway inflammation model.
Frontiers in microbiology · 2023-01 · Kim HS, Kim B, Holzapfel WH 외 1
- Disturbance of lipid metabolism in germ-free mice transplanted with gut microbiota of DSS-induced colitis mice.
PloS one · 2023-01 · Lee C, Kim S, Kim B 외 2
- Effect of Oral Intake of Lactiplantibacillus plantarum APsulloc 331261 (GTB1TM) on Diarrhea-Predominant Irritable Bowel Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study.
Nutrients · 2022-05 · Jung K, Kim A, Lee JH 외 6
- Characterization and safety evaluation of two beneficial, enterocin-producing Enterococcus faecium strains isolated from kimchi, a Korean fermented cabbage.
Food microbiology · 2022-04 · Valledor SJD, Dioso CM, Bucheli JEV 외 6
- Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts.
Microorganisms · 2021-10 · Park H, Arellano K, Lee Y 외 4
Patents
KIPRIS · applicant-matchedUS · Published · 2025-12 · Application 19408578
US · Published · 2025-12 · Application 19407179
PCT · Published · 2025-09 · Application PCT/KR2025/014405
PCT · Published · 2025-06 · Application PCT/KR2025/007605
PCT · Published · 2025-05 · Application PCT/KR2025/006462
PCT · Published · 2025-04 · Application PCT/KR2025/004950
US · Published · 2025-03 · Application 19087756
Published · 2025-03 · Application 1020250031323
- Subsidiary: 주식회사 로그미개체의 심폐체력을 예측하는 장치 및 방법
Registered · 2025-01 · Application 1020250012161
Published · 2024-11 · Application 1020240170940
Show 90 more patents
- Subsidiary: 주식회사 로그미개체의 근육 건강을 평가하는 방법 및 장치
Registered · 2024-11 · Application 1020240160209
PCT · Published · 2024-11 · Application PCT/KR2024/017426
- Subsidiary: 주식회사 로그미사용자 건강 상태와 생활 습관에 기반한 건강 상태 판정 및 맞춤형 건강 기능 식품 추천 시스템과 그 방법
Registered · 2024-11 · Application 1020240154116
Published · 2024-10 · Application 1020240146706
US · Published · 2024-10 · Application 18919581
- Subsidiary: 주식회사 로그미사용자 빅데이터 기반 열량 섭취량 예측 시스템 및 방법
Registered · 2024-09 · Application 1020240122741
PCT · Published · 2024-08 · Application PCT/KR2024/013066
Published · 2024-07 · Application 1020240089727
Registered · 2024-07 · Application 1020240089642
- Subsidiary: 주식회사 로그미균형적인 음식 섭취를 위한 음식 영양 판정 시스템 및 방법
Registered · 2024-07 · Application 1020240087460
- Subsidiary: 주식회사 로그미개인 맞춤형 운동 계획 서비스 제공 시스템 및 방법
Registered · 2024-06 · Application 1020240076049
PCT · Published · 2024-06 · Application PCT/KR2024/007776
PCT · Published · 2024-06 · Application PCT/KR2024/007773
Published · 2024-05 · Application 1020240069779
Rejected · 2023-12 · Application 1020230179005
US · Published · 2023-11 · Application 18518682
US · Published · 2023-11 · Application 18518698
Registered · 2023-10 · Application 1020230148050
PCT · Published · 2023-09 · Application PCT/KR2023/015076
Published · 2023-09 · Application 1020230130669
Registered · 2023-09 · Application 1020230120611
US · Registered · 2023-09 · Application 18463413
US · Registered · 2023-09 · Application 18460796
US · Published · 2023-09 · Application 18459463
US · Published · 2023-09 · Application 18459508
US · Published · 2023-08 · Application 18458297
Registered · 2023-06 · Application 1020230073106
Registered · 2023-06 · Application 1020230073105
Registered · 2023-04 · Application 1020230045416
PCT · Published · 2023-03 · Application PCT/KR2023/004281
US · Published · 2023-03 · Application 18181387
- Subsidiary: 주식회사 로그미건강나이를 예측하는 장치 및 방법
Registered · 2022-07 · Application 1020220090019
Registered · 2022-07 · Application 2020220001645
PCT · Published · 2022-05 · Application PCT/KR2022/007414
PCT · Published · 2022-05 · Application PCT/KR2022/007419
PCT · Published · 2022-05 · Application PCT/KR2022/007418
PCT · Published · 2022-05 · Application PCT/KR2022/007416
Registered · 2022-04 · Application 1020220052727
PCT · Published · 2022-03 · Application PCT/KR2022/003980
PCT · Published · 2022-03 · Application PCT/KR2022/003982
PCT · Published · 2022-03 · Application PCT/KR2022/003978
PCT · Published · 2022-03 · Application PCT/KR2022/003898
PCT · Published · 2022-03 · Application PCT/KR2022/003896
- Method for screening personalized intestinal environment-improving material and composition therefor
US · Registered · 2021-12 · Application 17645451
US · Registered · 2021-12 · Application 18259441
EP · Published · 2021-12 · Application 21915605.6
PCT · Published · 2021-12 · Application PCT/KR2021/018915
PCT · Published · 2021-09 · Application PCT/KR2021/012253
Registered · 2021-09 · Application 1020210119937
Registered · 2021-08 · Application 1020210106214
Rejected · 2021-05 · Application 1020210066612
Rejected · 2021-05 · Application 1020210066614
Registered · 2021-05 · Application 1020210066616
Registered · 2021-05 · Application 1020210066613
US · Published · 2021-03 · Application 17610600
PCT · Published · 2021-03 · Application PCT/KR2021/003850
Registered · 2021-03 · Application 1020210039432
Registered · 2021-03 · Application 1020210039435
Registered · 2021-03 · Application 1020210039434
Registered · 2021-03 · Application 1020210039437
Registered · 2021-03 · Application 1020210039433
Registered · 2021-01 · Application 1020210008188
US · Registered · 2020-12 · Application 17760112
EP · Published · 2020-12 · Application 20917302.0
PCT · Published · 2020-12 · Application PCT/KR2020/019432
Registered · 2020-12 · Application 1020200184265
US · Published · 2020-12 · Application 17793855
US · Published · 2020-12 · Application 17793836
PCT · Published · 2020-12 · Application PCT/KR2020/018343
PCT · Published · 2020-12 · Application PCT/KR2020/018347
Registered · 2020-10 · Application 1020200136235
Registered · 2020-06 · Application 1020200075590
Registered · 2020-06 · Application 1020200071492
Withdrawn · 2020-04 · Application 1020200044762
Withdrawn · 2020-02 · Application 1020200015876
Registered · 2020-02 · Application 1020200013674
EP · Registered · 2020-01 · Application 20856035.9
Rejected · 2020-01 · Application 1020200009521
Registered · 2020-01 · Application 1020200009519
Registered · 2019-12 · Application 1020190164960
Registered · 2019-12 · Application 1020190164936
Registered · 2019-12 · Application 1020190164967
Registered · 2019-12 · Application 1020190165048
Registered · 2019-12 · Application 1020190164973
Registered · 2019-12 · Application 1020190164943
Registered · 2019-12 · Application 1020190164913
Registered · 2019-12 · Application 1020190164953
Registered · 2019-12 · Application 1020190164928
Registered · 2019-08 · Application 1020190107146
Rejected · 2018-02 · Application 1020180022939
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Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
- Company basics
- Korea Exchange · DART
- Business content
- Compiled from disclosure filings
- Approvals & clinical trials
- Korean MFDS (data.go.kr) · US FDA openFDA — updated weekly
- Key disclosures
- KRX KIND via OpenDART exchange filings — updated daily
- Global clinical trials
- ClinicalTrials.gov (US NIH) — sponsor-matched, updated weekly
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- DART corporate disclosure filings — annual
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- Measured 2026-10-01
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