CRONEX.CO.,LTD
Develops multi-transgenic minipigs for xenotransplantation using native Jeju pigs as source animals.
As of 2026-10-10, CRONEX.CO.,LTD has 19 PubMed-indexed papers on record (counted by the MAA Company Index from its own matching of public databases).
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Business overview
Source: DART corporate disclosureFounded in 2012 and listed on KONEX in 2015, Cronex is a CDMO specializing in xenotransplantation and minipigs. Using native Jeju pigs as source animals and CRISPR/Cas9 and Cpf1 gene editing, it simultaneously knocks out three or more genes -- alpha-Gal, CMAH, and beta4GALNT2 -- and inserts human immune genes MCP and TBM to develop multi-transgenic pigs with 6-7 edited genes for xenotransplant organ production. In March 2021 it completed a test transplanting the kidney, heart, cornea, and skin of a triple-knockout minipig into a primate simultaneously; it operates an SPF-grade breeding facility in Cheongju and is building the Jeju Minipig Research Center (JMRC), with capacity for 700 concurrently bred animals and annual production of over 1,000, and holds or has filed 6 related patents.
Products & technology
- Transgenic minipig for xenotransplantationProduction of organs for human transplantation (kidney, heart, cornea, skin, etc.)
- Jeju minipig (JMRC-bred)Source animal for preclinical CRO drug and medical device testing
- Medical xenogeneic biomaterials (bio-ink, collagen, cartilage, etc.)Materials for 3D printer bio-ink and medical collagen/cartilage
R&D and key agreements
Source: DART corporate disclosure다중형질전환돼지 개발 · 이종장기이식 · 영장류 이식시험 완료 · Developing pigs with 6-7 edited genes through knockout of immune rejection genes (alpha-Gal, CMAH, beta4GALNT2) and knock-in of human MCP and TBM genes
소형종 미니돼지 개발(비임상 모델) · 육종 및 검증 중 · Since 2015, selectively breeding native Jeju pigs (adult weight 60-80kg) over 7 generations to produce source animals half the size of the original breed
Key disclosures
KRX KIND via OpenDARTPublications
PubMed · affiliation-matched- Generation and ophthalmological characterization of oculocutaneous albinism type 1 pig models by selection-free genome editing.
Scientific reports · 2025-12 · Oh D, Seok C, Park HW 외 12
- Generation of a genetically engineered porcine melanoma model featuring oncogenic control through conditional Cre recombination.
Scientific reports · 2025-01 · Oh D, Hong N, Eun K 외 12
- Preliminary research on tailored fluid therapy in pigs: comparing customized ionic solutions with Hartmann's solution.
BMC veterinary research · 2024-06 · Lee S, Lee SE, Han JI 외 2
- Analysis of blood composition by porcine breeding cycle.
Veterinary medicine and science · 2024-03 · Lee S, Lee SC, Jeon Y
- Piperine improves the quality of porcine oocytes by reducing oxidative stress.
Free radical biology & medicine · 2024-03 · Lim ES, Lee SE, Park MJ 외 5
- Ellagic acid treatment during in vitro maturation of porcine oocytes improves development competence after parthenogenetic activation and somatic cell nuclear transfer.
Theriogenology · 2024-02 · Lee HB, Lee SE, Park MJ 외 5
- Improvement of weanling pigs immune status and metabolic condition using ultraweak light.
Journal of animal physiology and animal nutrition · 2024-01 · Lee CB, Hosseindoust A, Ha SH 외 7
- DRG2 in macrophages is crucial for initial inflammatory response and protection against Listeria monocytogenes infection.
Clinical immunology (Orlando, Fla.) · 2023-12 · Lee UH, Park SJ, Ju SA 외 10
- Bacillus-supplemented diet improves growth performance in Jeju native pigs by modulating myogenesis and adipogenesis.
Animal biotechnology · 2023-11 · Kim D, Min Y, Suminda GGD 외 7
- Current Status of Genetically Engineered Pig to Monkey Kidney Xenotransplantation in Korea.
Transplantation proceedings · 2023-05 · Hwang SA, Park KS, Kim WS 외 10
Show 9 more publications
- Oropharyngeal, proximal colonic, and vaginal microbiomes of healthy Korean native black pig gilts.
BMC microbiology · 2023-01 · Bugenyi AW, Lee MR, Choi YJ 외 7
- High-quality metagenome-assembled genomes from proximal colonic microbiomes of synbiotic-treated korean native black pigs reveal changes in functional capacity.
Scientific reports · 2022-09 · Jung J, Bugenyi AW, Lee MR 외 8
- Innate Immune Response Analysis in Meniscus Xenotransplantation Using Normal and Triple Knockout Jeju Native Pigs.
International journal of molecular sciences · 2022-09 · Yoon S, Min Y, Park C 외 7
- An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs.
Vaccines · 2022-09 · Yoon S, Lee S, Park C 외 10
- Generation of reproductive transgenic pigs of a CRISPR-Cas9-based oncogene-inducible system by somatic cell nuclear transfer.
Biotechnology journal · 2022-07 · Eun K, Hwang SU, Kim M 외 16
- Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus.
International journal of molecular sciences · 2021-08 · Kim EJ, Kwon OS, Hur CG 외 5
- Growth factors improve the proliferation of Jeju black pig muscle cells by regulating myogenic differentiation 1 and growth-related genes.
Animal bioscience · 2021-08 · Park J, Lee J, Song KD 외 6
- Multi-Probiotic Lactobacillus Supplementation Improves Liver Function and Reduces Cholesterol Levels in Jeju Native Pigs.
Animals : an open access journal from MDPI · 2021-08 · Kim D, Min Y, Yang J 외 9
- Genome-wide scans for detecting the selection signature of the Jeju-island native pig in Korea.
Asian-Australasian journal of animal sciences · 2020-04 · Lee YS, Shin D, Won KH 외 3
Patents
KIPRIS · applicant-matchedPublished · 2025-01 · Application 1020250004141
Published · 2024-12 · Application 1020240189701
Registered · 2023-07 · Application 1020230089850
- Subsidiary: (주)에스에이치랩무역관리컴퓨터, 무역관리시스템 및 무역관리방법
Registered · 2021-10 · Application 1020210143587
Registered · 2020-06 · Application 1020200074533
Registered · 2016-12 · Application 1020160181385
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Sources and updates
Counts on this page are not company-reported figures. MAA matched records from DART, the Korean MFDS, the US FDA, ClinicalTrials.gov, PubMed and KIPRIS to this company itself, by business registration number or registered name, never by name similarity. They may differ from figures the company publishes.
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- Measured 2026-10-01
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